Results 101 to 110 of about 1,694,294 (282)

Effects of clothianidin exposure during pregnancy and lactation on the thyroid function of maternal rats and the early neurodevelopment of offspring

Guangxi Yike Daxue xuebao
Objective To investigate the effects of clothianidin (CLO) exposure on the thyroid function of mater‐nal rats and the early neurodevelopment of their offspring by establishing a CLO exposure model in SpragueDawley (SD) rats during pregnancy and lactation.
Xiaorong HUANG, Wanhui LI, Junshang WEN, Liujuan OU, Junwang GU, Huishen HUANG, Ying YANG, Qihua ZHU, Kaiqi YANG, Xin QIN, Dongping HUANG   +10 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source

Effectiveness of reflex integration approach and play therapy on functionality in patients with spastic cerebral palsy: a comparative study

Bulletin of Faculty of Physical Therapy
Background Cerebral palsy (CP) is a group of permanent disorders affecting movement and posture due to non-progressive damage to the developing brain.
Nidhi V. Patel, Anjan Rajeshkumar Desai
doaj   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Medial olivocochlear reflex in ankylosing spondylitis patients

, 2016
Celiker, Metin/0000-0002-9833-402X; Serdaroglu Beyazal, Munevver/0000-0001-5903-5708Ankylosing spondylitis (AS) is a chronic systemic inflammatory disease. Via autoimmune mediators, AS can damage the auditory system similar to other systems.
Özgür, Abdulkadir, Terzi, Suat, Beyazal, Münevver Serdaroğlu, Çeliker, Metin, Dursun, Engin, BEYAZAL, MEHMET, Özgür, A.   +6 more
core   +1 more source

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

The trigemino-cardiac reflex: An update of the current knowledge

, 2009
The trigemino-cardiac reflex (TCR) is clinically defined as the sudden onset of parasympathetic activity, sympathetic hypotension, apnea, or gastric hypermotility during central or peripheral stimulation of any of the sensory branches of the trigeminal ...
H. Prabhakar, Koerbel, Andrei, Gnanalingham, Kanna, G. Ottaviani, N. Sandu, B. Schaller, K. Gnanalingham, Trigemino Cardiac Reflex Examination Group, Schaller, Bernhard, A. Filis, Prabhakar, Hemanshu, J. F. Cornelius, M. Buchfelder, Sandu, Nora, Ottaviani, Giulia, Buchfelder, Michael, Filis, Andreas, A. Koerbel, Cornelius, Jan F., Andreas Filis, Michael Buchfelder, Giulia Ottaviani, Jan F. Cornelius, Hemanshu Prabhakar, Nora Sandu, Bernhard Schaller, Kanna Gnanalingham, Andrei Koerbel   +27 more
core   +1 more source

High‐Performance Piezoresistive Sensors via Pd/Sn‐Free Graphene‐Catalyzed Metallization of Thermally Repairable Microfiber Scaffolds

Advanced Science, EarlyView.
The multilayer fiber‐based PGC sensor, fabricated via graphene‐mediated electroless copper deposition, demonstrates high sensitivity, mechanical durability, and fast response speed. Additionally, it features low‐temperature thermal assisted recovery and thermal resistance, providing a promising platform for wearable electronic devices and IoT ...
ByungJun Kim, Su Bin Choi, Yeonwook Jeong, Jeong‐Won Yoon, Seung‐Boo Jung, Jong‐Woong Kim   +5 more
wiley   +1 more source