Results 101 to 110 of about 19,908 (254)

Comparing the Effect of Intravenous Midazolam with Rectal Sodium Valproate in Controlling of Children with Refractory Status Epilepticus

Journal of Research in Medical Sciences, 2006
Background: Refractory status epilepticus usually defined as a seizure lasting at least 60 minutes which is uncontrollable by Diazepam, Phenytoin, or Phenobarbital.
T Mahmoudian, M Najafian
doaj  

Subunit Composition of Neurotransmitter Receptors in the Immature and in the Epileptic Brain [PDF]

, 2014
Neuronal activity is critical for synaptogenesis and the development of neuronal networks. In the immature brain excitation predominates over inhibition facilitating the development of normal brain circuits, but also rendering it more susceptible to ...
Loddenkemper, Tobias, Sánchez Fernández, Iván   +1 more
core   +1 more source

Rapid recovery after intrathecal dexamethasone in FIRES

Epileptic Disorders, EarlyView.
João Filipe Nico, Ana Rita Fradique, Catarina Teixeira, Rita Moinho, Mariana Leitão Marques, Constança Santos, Joana Afonso Ribeiro, Filipe Palavra, Cristina Pereira   +8 more
wiley   +1 more source

Patterns of seizure frequency reduction in clinical trial participants with lower baseline seizure frequency

Epilepsia, EarlyView.
Abstract Objective Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double‐blind period. To inform the selection of seizure frequency‐based inclusion criteria, we evaluated the association between ...
Wesley T. Kerr, Advith S. Reddy, Neo Kok, Katherine N. McFarlane, Lavanya Biju, Jacqueline A. French   +5 more
wiley   +1 more source

Surgical management of status epilepticus: A systematic review

Epilepsia Open
Status Epilepticus (SE), unresponsive to medical management, is associated with high morbidity and mortality. Surgical management is typically considered in these refractory cases. The best surgical approach for affected patients remains unclear; however,
Rohan Jha, Sarah E. Blitz, Melissa M. J. Chua, Aaron E. L. Warren, Jong Woo Lee, John D. Rolston   +5 more
doaj   +1 more source

Network structure determines patterns of network reorganization during adult neurogenesis [PDF]

, 2009
New cells are generated throughout life and integrate into the hippocampus via the process of adult neurogenesis. Epileptogenic brain injury induces many structural changes in the hippocampus, including the death of interneurons and altered connectivity ...
Ben-Jacob, Eshel, Parent, Jack M., Sander, Leonard M., Schneider-Mizell, Casey M., Zochowski, Michal   +4 more
core  

Rational polytherapy in the treatment of cholinergic seizures. [PDF]

, 2020
The initiation and maintenance phases of cholinergic status epilepticus (SE) are associated with maladaptive trafficking of synaptic GABAA and glutamate receptors.
Baldwin, Roger, Estrada, Ireri Betsabe Franco, Furtado, Marcio de Araujo, Lumley, Lucille, Naylor, David, Niquet, Jerome, Rossetti, Franco, Schultz, Mark, Suchomelova, Lucie, Wasterlain, Claude G   +9 more
core  

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

Bowel Ischemia: A Rare Complication of Thiopental Treatment for Status Epilepticus [PDF]

, 2018
Background: Refractory status epilepticus (RSE) treatment is usually performed with comainduction using an appropriate general anesthetic. Most frequent complications are represented by hypotension and infection.
Berger, Mette, Cereda, Carlo, Rossetti, Andrea   +2 more
core  

Super Refractory Status Epilepticus

, 2017
Earlier definitions of status epilepticus (SE) were based on the duration of seizures, but newer definitions rely more on a pragmatic staging based on treatment failures (Table 23.1). Refractory status epilepticus (RSE) is defined as SE that continues despite administration of both benzodiazepines and an appropriately dosed second-line antiseizure drug.
Zachariah, Joseph, Britton, Jeff, Hocker, Sara   +2 more
openaire   +1 more source