Results 51 to 60 of about 1,397,234 (360)

Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo

Stem Cell Research & Therapy, 2020
Background In recent years, significant progress has been made in developing highly complex tissue-engineered skin substitutes (TESSs) for wound healing. However, the lack of skin appendages, such as hair follicles and sweat glands, and the time required,
Qun Zhang, Jie Wen, Chang Liu, Chuan Ma, Fuxiang Bai, Xue Leng, Zhihong Chen, Zhiwei Xie, Jun Mi, Xunwei Wu   +9 more
doaj   +1 more source

Nerve commitment in Hydra. I. Role of morphogenetic signals [PDF]

, 1981
The kinetics of nerve commitment during head regeneration in Hydra were investigated using a newly developed assay for committed cells. Committed nerve precursors were assayed by their ability to continue nerve differentiation following explanation of ...
Berking, Bode, Bode, Bode, Bode, Campbell, David, David, David, David, David, Gierer, Hicklin, MacWilliams, MacWilliams, MacWilliams, Schaller, Sproull, Sproull, Tardent, Venugopal, Venugopal, Webster, Webster, Wolpert, Yaross   +25 more
core   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Chalk and Cheese: A comparison of England and Scotland’s emerging approaches to regeneration [PDF]

, 2012
To suggest that the Department for Communities and Local Government’s (DCLG’s) publication Regeneration to Enable Growth: What Government Is Doing in Support of Community-Led Regeneration, issued in early 2011, was a disappointment to many is something ...
Errington, Barry, Furness, Hannah, Greenhalgh, Paul, McGuinness, David, Pugalis, Lee   +4 more
core  

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

Human α-synuclein aggregation activates ferroptosis leading to parvalbumin interneuron degeneration and motor learning impairment

Communications Biology
The accumulation of α-synuclein induces neuronal loss in midbrain nuclei and leads to the disruption of motor circuits, while the pathology of α-synuclein in cortical regions remains elusive.
Borui Zhang, Kai Chen, Yelin Dai, Xi Luo, Ziwei Xiong, Weijia Zhang, Xiaodan Huang, Kwok-Fai So, Li Zhang   +8 more
doaj   +1 more source

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

Disease Models & Mechanisms, 2019
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger   +9 more
doaj   +1 more source

CUL4B Upregulates RUNX2 to Promote the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Epigenetically Repressing the Expression of miR-320c and miR-372/373-3p

Frontiers in Cell and Developmental Biology, 2022
Mesenchymal stem cells (MSCs) within the periodontal ligament (PDL), termed periodontal ligament stem cells (PDLSCs), have a self-renewing capability and a multidirectional differentiation potential.
Jun Mi, Jun Mi, Shuangshuang Wang, Panpan Liu, Panpan Liu, Chang Liu, Dexuan Zhuang, Xue Leng, Qun Zhang, Fuxiang Bai, Qiang Feng, Xunwei Wu, Xunwei Wu, Xunwei Wu   +13 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source