Results 61 to 70 of about 1,531,393 (333)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

The Regeneration Games: Commodities, Gifts and the Economics of London 2012 [PDF]

, 2008
This paper considers contradictions between two concurrent and tacit conceptions of the Olympic ‘legacy’, setting out one conception that understands the games and their legacies as gifts alongside and as counterpoint to the prevailing discourse, which ...
Amin A., Auge Mark, Barney R., Boddy M., Booth D., Bowyer M., Burbank M., Chappelet J.-L., Donovan P., Evans G., Frow J., Frow J., Furrer P., Gavin Poynter, Gold John, Gregory Chris, Hamnett C., Hopsicker Peter, Hyde L., Iain Macrury, Komter A., Lee M., London Organizing Committee of the Olympic Games (LOCOG), Malinowski B., Mauss M., Mayor of London, National Audit Office, National Audit Office, Newham Council, Offer A., Parkinson M., Philostratus, Polanyi K., Polanyi Karl, Poynter G., Poynter G., Putnam Robert, Roche M., Sahlins M., Sennett R., Young Kevin   +40 more
core   +2 more sources

Cartilage Regeneration [PDF]

Journal of the American Academy of Orthopaedic Surgeons, 2013
Cartilage damaged by trauma has a limited capacity to regenerate. Current methods of managing small chondral defects include palliative treatment with arthroscopic débridement and lavage, reparative treatment with marrow-stimulation techniques (eg, microfracture), and restorative treatment, including osteochondral grafting and autologous chondrocyte ...
Rocky S, Tuan, Antonia F, Chen, Brian A, Klatt   +2 more
openaire   +2 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Wheel Running Improves Motor Function and Spinal Cord Plasticity in Mice With Genetic Absence of the Corticospinal Tract

Frontiers in Cellular Neuroscience, 2019
Our previous studies showed that mutant mice with congenital absence of the corticospinal tract (CST) undergo spontaneous remodeling of motor networks to partially compensate for absent CST function.
Wei Zhang, Bin Yang, Huandi Weng, Tao Liu, Lingling Shi, Panpan Yu, Kwok-Fai So, Yibo Qu, Libing Zhou, Libing Zhou, Libing Zhou   +10 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges

Translational Neurodegeneration, 2023
In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and progressive neurodegenerative disease with heterogeneous clinical presentations, researchers have generated numerous animal models to mimic the genetic defects ...
Longhong Zhu, Shihua Li, Xiao-Jiang Li, Peng Yin   +3 more
doaj   +1 more source

Kidney regeneration: common themes from the embryo to the adult [PDF]

, 2013
The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function ...
Cirio, Maria Cecilia, Davidson, Alan J., de Caestecker, Mark P., de Groh, Eric D., Hukriede, Neil A.   +4 more
core   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. [PDF]

, 2016
The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus.
Asahara, Hiroshi, Ichinose, Shizuko, Inagawa, Masayo, Inui, Masafumi, Ito, Yoshiaki, Kataoka, Kensuke, Kayama, Tomohiro, Lotz, Martin K, Masuda, Koichi, Mori, Masaki, Nakamichi, Ryo, Onizuka, Naoko, Ozaki, Toshifumi, Sakai, Daisuke, Suzuki, Hidetsugu   +14 more
core   +1 more source