Results 61 to 70 of about 1,660,190 (291)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

'It'll get worse before it gets better': Local experiences of living in a regeneration area [PDF]

, 2013
The negative consequences of living in deprived neighbourhoods for residents’ quality of life are well documented. Area-based regeneration initiatives are invariably concerned with improving local quality of life over the long term.
Braidford, Paul, Davidson, Gill, Greenhalgh, Paul, McGuinness, David, Robinson, Fred   +4 more
core  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Multilevel Diversity Coding with Secure Regeneration: Separate Coding Achieves the MBR Point

, 2017
The problem of multilevel diversity coding with secure regeneration (MDC-SR) is considered, which includes the problems of multilevel diversity coding with regeneration (MDC-R) and secure regenerating code (SRC) as special cases.
Liu, Tie, Shao, Shuo, Shen, Cong, Tian, Chao   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Viral Vector-based Improvement of Optic Nerve Regeneration: Characterization of Individual Axons\u27 Growth Patterns and Synaptogenesis in a Visual Target [PDF]

, 2015
Lack of axon growth ability in the central nervous system poses a major barrier to achieving functional connectivity after injury. Thus, a non-transgenic regenerative approach to reinnervating targets has important implications in clinical and research ...
Blackmore, Murray G., Luo, Xueting, Salgueiro, Yadira, Yungher, Benjamin J.   +3 more
core   +1 more source

Detailed design of a resonantly-enhanced axion-photon regeneration experiment [PDF]

, 2009
A resonantly-enhanced photon-regeneration experiment to search for the axion or axion-like particles is described. This experiment is a shining light through walls study, where photons travelling through a strong magnetic field are (in part) converted to
A. A. Ansel’m, A. E. Siegman, A. P. Zhitnitskii, D. B. Tanner, G. G. Raffelt, Guido Mueller, Karl van Bibber, Pierre Sikivie   +7 more
core   +2 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Advanced Science, 2023
Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be ...
Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li   +16 more
doaj   +1 more source

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]

, 2016
Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin, Brennan-Minnella, Angela M, Cho, Sung-Woo, Hwang, Inwoo, Jin, Eun-Ju, Ko, Hyo Rim, Kwon, Il-Sun, Lee, Kyung-Hoon, Shin, Joo-Ho, Swanson, Raymond   +9 more
core   +2 more sources