Stem Cell Reports, 2014 In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model ...
Juthaporn Assawachananont +7 more
doaj +1 more source
Nerve commitment in Hydra. II. Localization of commitment in S phase [PDF]
, 1981 The kinetics of nerve differentiation were investigated during head regeneration in Hydra. In particular the cell cycle parameters of stem cells undergoing nerve commitment were determined.
Berking +15 more
core +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Graft survival of major histocompatibility complex deficient stem cell-derived retinal cells
Communications MedicineBackground Gene editing of immunomodulating molecules is a potential transplantation strategy to control immune rejection. As we noticed the successful transplantation of retinal pigment epithelium (RPE) derived from embryonic stem cells of a cynomolgus ...
Masaaki Ishida +7 more
doaj +1 more source
Modulation of TNFα Activity by the microRNA Let-7 Coordinates Zebrafish Heart Regeneration
iScience, 2019 Summary: The adult zebrafish is capable of regenerating heart muscle, resolving collagen tissue, and fully restoring heart function throughout its life. In this study, we show that the highly upregulated, epicardium-enriched microRNA let-7i functions in ...
Ashley M. Smith +3 more
doaj +1 more source
Temporal Dynamics and Heterogeneity of Cell Populations during Skeletal Muscle Regeneration
iScience, 2020 Summary: Mammalian skeletal muscle possesses a unique ability to regenerate, which is primarily mediated by a population of resident muscle stem cells (MuSCs) and requires a concerted response from other supporting cell populations.
Stephanie N. Oprescu +4 more
doaj +1 more source
Monocyte-derived Kupffer cells dominate in the Kupffer cell pool during liver injury
Cell Reports, 2023 Summary: Healthy Kupffer cell (KC) pool is dominated by embryonic KCs (EmKCs), preserving liver homeostasis. How the KC pool varies upon injury remains unclear.
Weiyang Li +4 more
doaj +1 more source
A monoclonal antibody that blocks the activity of a neurite regeneration-promoting factor: studies on the binding site and its localization in vivo [PDF]
, 1986 Work from several laboratories has identified a proteoglycan complex secreted by a variety of non-neuronal cells that can promote neurite regeneration when applied to the surface of culture dishes.
Chiu, Arlene Y. +2 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Commitment during stenotele differentiation in Hydra is localized near the S/G2 boundary in the terminal cell cycle [PDF]
, 1982 The timing of commitment during stenotele differentiation in Hydra was determined. Regeneration of isolated distal regions of the body column induces stenotele differentiation.
Berking +16 more
core +1 more source