Results 191 to 200 of about 277,643 (298)

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Digital OTAs: Conventional Designs Versus Emerging Concept

Akbari M, Covi E, Gibertini P.
europepmc   +1 more source

Adipose-muscle crosstalk during the menopausal transition: mechanistic links to sarcopenic obesity in midlife women. [PDF]

Front Endocrinol (Lausanne)
Zhang W, Wu Q, Chen Q, Qin W, Zhang D, Xu Q, Han P, Sun J.   +7 more
europepmc   +1 more source

Strong Metal‐Support Interaction Driven Janus Reconstruction in PtRu Alloys for Low‐Temperature Hydrogen Storage

Advanced Science, EarlyView.
Strong metal‐support interactions (SMSI) drive the spontaneous segregation of RuPt alloy into Janus nanoparticles on CeO2, spatially partitioning Pt‐rich domains for H2 dissociation and Ru‐rich domains for toluene adsorption. This Janus nanocatalysts yield a turnover frequency of 10 906 h−1 for toluene hydrogenation at 50 °C, which is 6.7 times that of
Xingyu Zhang, Haiqiang Bai, Wenbin Li, You Wang, Yunhua Xu, Sai Zhang   +5 more
wiley   +1 more source

The vicious cycle of SASP and inflammaging promotes aging and age-related diseases. [PDF]

Commun Biol
Liu Q, Zheng Y, Sun C.
europepmc   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Correction: 10 kHz repetition rate picosecond green laser for high-accuracy satellite ranging

Frontiers in Physics
Zhongwei Fan, Zhongwei Fan, Xiaopeng Liu, Xiaopeng Liu, Zhongping Zhang, Wendong Meng, Mingliang Long, Zhenao Bai   +7 more
doaj   +1 more source

A Cost-Effective and Minimally Invasive Protocol for Chronic Multi-Site Electroencephalography Recording in Freely Moving Mice. [PDF]

J Vis Exp
Radeen KR, Shanazz K, Hao C, Weiss DL, Blake DT, Fan X.   +5 more
europepmc   +1 more source

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

Advanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li, Rui Fan, Kun Xie, Jiehua Zhong, Yitong Zhu, Tingting Ji, Yuanyuan Qin, Shijin Peng, Yu Zhang, Yuhang Guo, Tiange Zhang, Chunchen Liu, Bo Li, Lei Zheng, Ye Zhang, Xiaohui Yan   +15 more
wiley   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source