Results 111 to 120 of about 216,180 (312)

Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability

, 2011
Spinal cord regenerative ability is lost with development, but the mechanisms underlying this loss are still poorly understood. In chick embryos, effective regeneration does not occur after E13, when spinal cord injury induces extensive apoptotic ...
Lange, S., Yeung K-Y, Nicholas, A.P., Thompson, P.R., Ferretti, P., Causey, C.P., Gogel, S., Greene, N.D.E.   +7 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Regenerative Effect of Mesenchymal Stem Cell on Cartilage Damage in a Porcine Model. [PDF]

Biomedicines, 2023
Lin SC, Panthi S, Hsuuw YH, Chen SH, Huang MJ, Sieber M, Hsuuw YD.   +6 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Immune remodelling of stromal cell grafts in the central nervous system : therapeutic inflammation or (harmless) side-effect?

, 2017
: Over the past two decades, several cell types with fibroblast-like morphology, including mesenchymal stem/stromal cells, but also other adult, embryonic and extra-embryonic fibroblast-like cells, have been brought forward in the search for cellular ...
Ponsaerts, Peter, De Vos, WinnokUGent002000617421801001764043975654627528F6CF352E-F0ED-11E1-A9DE-61C894A0A6B4, Hoornaert, Chlo\ue9, Berneman, Zwi Nisan, Detrez, Jan, Le Blon, Debbie, Hoornaert, Chloé, Goossens, Herman, Berneman, Zwi, Detrez, Jan R, De Vos, Winnok, Daans, Jasmijn, Bevers, Sanne   +12 more
core   +1 more source

On the stability of high-speed milling with spindle speed variation [PDF]

, 2010
Spindle speed variation is a well-known technique to suppress regenerative machine tool vibrations, but it is usually considered to be effective only for low spindle speeds.
Arnaud, Lionel, Insperger, Tamás, Peigné, Grégoire, Seguy, Sébastien, Dessein, Gilles   +4 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Comparative transcriptomic profiling reveals a role for Olig1 in promoting axon regeneration

Cell Reports
Summary: The regenerative potential of injured axons displays considerable heterogeneity. However, the molecular mechanisms underlying the heterogeneity have not been fully elucidated.
Xiu-Qing Fu, Wen-Rong Zhan, Wei-Ya Tian, Peng-Ming Zeng, Zhen-Ge Luo   +4 more
doaj   +1 more source

Variations in Persistence and Regenerative Zones in Coastal Forests Triggered by Sea Level Rise and Storms

Remote Sensing, 2019
Retreat of coastal forests in relation to sea level rise has been widely documented. Recent work indicates that coastal forests on the Delmarva Peninsula, United States, can be differentiated into persistence and regenerative zones as a function of sea ...
Sergio Fagherazzi, Giovanna Nordio, Keila Munz, Daniele Catucci, William S. Kearney   +4 more
doaj   +1 more source