Results 91 to 100 of about 5,049,311 (291)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 1922 Copia digital. Valladolid : Junta de Castilla y León.
Asociación Centro Región Leonesa (Buenos Aires)
core
Revista Atlántica-Mediterránea de Prehistoria y ArqueologÃa Social, 2015 El presente trabajo tiene como objetivo el de ofrecer un análisis de la ocupación paleolítica de las sociedades cazadoras-recolectores en la Región Geohistórica del Estrecho de Gibraltar, especialmente en los espacios que denominamos ‘’ambientes montañosos’’, marcados estos por su caracterización geográfica y geológica.
openaire +2 more sources
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
, 1920 Copia digital. Valladolid : Junta de Castilla y León.
Asociación Centro Región Leonesa (Buenos Aires)
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 1922 Copia digital. Valladolid : Junta de Castilla y León.
Asociación Centro Región Leonesa (Buenos Aires)
core
Back Matter Vol. 18 No.2 (2023)
Region: Jurnal Pembangunan Wilayah dan Perencanaan Partisipatif, 2023 Jurnal Region
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source