Results 101 to 110 of about 6,134,931 (285)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Revista mensual del Centro Región Leonesa: Revista mensual del Centro Región Leonesa - Año III Número 20 - 1921 marzo (01/03/1921) [PDF]

, 1921
Copia digital. Valladolid : Junta de Castilla y León.
Asociación Centro Región Leonesa (Buenos Aires)
core   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

[Artículo traducido] La edad influye en la eficacia de la transferencia autóloga osteocondral: resultados prometedores para pacientes menores de 40 años

Revista Española de Cirugía Ortopédica y Traumatología
Resumen: Antecedentes: Investigaciones previas en las que se ha utilizado el trasplante osteocondral autólogo (OAT) han mostrado peores resultados con el aumento de la edad del paciente. El objetivo de este artículo es evaluar a una cohorte de pacientes
F. Figueroa, D. Figueroa, R. Calvo, E. Stocker, M. Itriago, M. Nuñez   +5 more
doaj   +1 more source

Revista mensual del Centro Región Leonesa: Revista mensual del Centro Región Leonesa - Año V Número 47 - 1923 diciembre (01/12/1923) [PDF]

, 1923
Copia digital. Valladolid : Junta de Castilla y León.
Asociación Centro Región Leonesa (Buenos Aires)
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Distribución del Canon Minero y su incidencia en los Indicadores de Desarrollo Humano Región Ancash 2004-2014: Una propuesta de redistribución

INGnosis Revista de Investigación Científica, 2015
En el presente estudio se hace una revisión de las principales características y los montos de la distribución del canon minero y como estos, tanto en su forma más generalizada de aplicación como en las unidades de análisis, tiene correlación positiva o negativa, con el objetivo de determinar si han logrado o no mejorar los indicadores de ...
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source