Results 51 to 60 of about 3,060,494 (349)
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
USV Annals of Economics and Public Administration, 2016 Adrian-Liviu SCUTARIU, Cercetarea fenomenului turistic din perspectivă regională, Editura Didactică şi Pedagogică, Bucureşti, 2016, ISBN 978-606-31-0165-6, 460 p.
Carmen NASTASE
doaj
Book Review: Peter Batey, David Plane (Editors), Great Minds in Regional Science (Vol.2), Springer, 2023 [PDF]
Romanian Journal of Regional ScienceThe subseries Great Minds in Regional Science, along with the subseries The Voice of Regional Science, comprise the book series titled Footprints in Regional Science, published under The Regional Science Academy.
Christa D. Court
doaj +1 more source
SCIENCE-POLICY INTERFACE IN REGIONAL ENVIRONMENTAL MANAGEMENT: CASE OF HELCOM IN THE BALTIC CONTEXT
Соціальна економіка, 2023 The regional environmental cooperation in the Baltic Sea is the leading and “forerunner” model for managing environmental challenges at the regional level.
Uyanga Tsenddorj, Buyandelger Doljin
doaj +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Steady-state energy balance in animal models of obesity and weight loss [PDF]
, 2016 Supported by European Union Seventh Framework Programme (FP7/2007-2013, n°266408 (Full4Health)), the Joint Programme of the Medical Faculty of Norwegian University of Science and Technology (NTNU) and St. Olav’s University Hospital, the Liaison Committee
Barrett, Perry +7 more
core +2 more sources
Core-Periphery and Peripherality in Regional Science [PDF]
Prostranstvennaâ ÈkonomikaThe article presents an analytical review of the development of the core-periphery and peripherality concepts in economic theory. The stages of formation of the core-periphery approach are marked by the contributions of the school of Latin American ...
Larisa Victorovna Melnikova
doaj +1 more source