Results 61 to 70 of about 3,300,692 (345)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Problematyka metodologiczna studiów regionalnych

Studia Regionalne i Lokalne, 2005
Praca ta stanowi wprowadzenie do problematyki metodologicznej studiów regionalnych. Składa się z trzech części. Pierwsza część omawia charakter studiów regionalnych, do których zalicza się Regional Science jako reprezentacyjną formę instytucjonalno ...
Zbyszko Chojnicki
doaj  

Associations for Citizen Science: Regional Knowledge, Global Collaboration

Citizen Science: Theory and Practice, 2016
Since 2012, three organizations advancing the work of citizen science practitioners have arisen in different regions: The primarily US-based but globally open Citizen Science Association (CSA), the European Citizen Science Association (ECSA), and the ...
Martin Storksdieck, Jennifer Lynn Shirk, Jessica L. Cappadonna, Meg Domroese, Claudia Göbel, Muki Haklay, Abraham J. Miller-Rushing, Philip Roetman, Carla Sbrocchi, Katrin Vohland   +9 more
doaj   +1 more source

Exploring rural administrator perspectives of the decline in science and math secondary education graduates from a regional public university in a Midwestern state over the last ten years : a case study [PDF]

, 2021
Kelsey Powell
openalex   +1 more source

Journal portfolio analysis for countries, cities, and organizations: maps and comparisons [PDF]

, 2015
Using Web of Science data, portfolio analysis in terms of journal coverage can be projected onto a base map for units of analysis such as countries, cities, universities, and firms.
Blondel, Grossetti, Heimeriks, Leydesdorff, Matthiessen, Narin, Rafols, Rafols, Rao, Small, Stirling, Van Eck, Van Noorden, Waltman, Zhang, Zhang   +15 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Aggregate and Regional Economic Effects of New Railway Infrastructure [PDF]

Economists expect positive returns to investments in infrastructure. However a project with higher national returns might have less favorable effects on a regional level than the alternative.
Richard Sellner, Wolfang Polasek, Wolfang Schwarzbauer   +2 more
core   +4 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Współczesne studia regionalne – teoria i metodologia, a także praktyka

Studia Regionalne i Lokalne, 2004
Artykuł podejmuje próbę przekrojowego przedstawienia ewolucji sposobów definiowania i opisu regionów, wskazując na ich wzajemne wynikanie oraz logiczne następstwo kolejnych analitycznych koncepcji regionu.
Iwona Sagan
doaj