Results 71 to 80 of about 3,106,115 (349)

LANDMARKS IN THE EVOLUTION OF REGIONAL SCIENCE

USV Annals of Economics and Public Administration, 2015
This article approaches issues of regional science development, science that analyzes the phenomena and processes related to space, distance and location.
Adrian Liviu SCUTARIU
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Współczesne studia regionalne – teoria i metodologia, a także praktyka

Studia Regionalne i Lokalne, 2004
Artykuł podejmuje próbę przekrojowego przedstawienia ewolucji sposobów definiowania i opisu regionów, wskazując na ich wzajemne wynikanie oraz logiczne następstwo kolejnych analitycznych koncepcji regionu.
Iwona Sagan
doaj  

The science of space: new endeavours in regional science [PDF]

Asia-Pacific Journal of Regional Science, 2021
Kourtit, Karima, Nijkamp, Peter, Suzuki, Soushi   +2 more
openaire   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

The effects of regional scientific opportunities in science-technology flows: Evidence from scientific literature cited in firms' patent data [PDF]

From a spatial perspective, it is well known in the literature on innovation and technological change that scientific research undertaken in the universities plays an important role as an instrument for stimulating economic growth.
Daniel Coronado, Manuel Acosta
core  

Contemporary Regional Studies – Theory, Methodology and Practice

Studia Regionalne i Lokalne, 2006
The paper offers a review of the evolution in defining and describing regions, showing mutual relationships between particular approaches and logical succession between various analytical concepts of the region.
Iwona Sagan
doaj  

Japanese contributions to regional science

Papers in Regional Science, 2020
Given the field's interdisciplinary nature, regional scientists come with a wide spectrum of backgrounds. In this paper, we study the contributions to regional science made by scholars from Japan. First, we briefly examine how Japanese regional scientists came to develop a keen sense towards urban problems.
Ho Yeon Kim, Philip McCann
openaire   +2 more sources