Results 71 to 80 of about 45,110,513 (323)

Анализ документально-информационного потока по проблемам сибирского краеведения

open access: yesБиблиосфера, 2010
The characteristic of document and information flow on the problems of Siberian regional studies during 1991-2005 is given. The author makes bibliometrical analysis of quantitative changes in document and information flow, its type and aspect and ...

doaj  

Delimitation and Classification of Rural Areas in Hungary [PDF]

open access: yesRomanian Review of Regional Studies, 2016
The present study relies on the outcomes of a complex rural research programme based on the cooperation between the Hungarian Academy of Sciences and the Hungarian National Rural Network.
ÉVA PERGER   +2 more
doaj  

Microglial regional heterogeneity and its role in the brain

open access: yesMolecular Psychiatry, 2019
Microglia have been recently shown to manifest a very interesting phenotypical heterogeneity across different regions in the mammalian central nervous system (CNS). However, the underlying mechanism and functional meaning of this phenomenon are currently
Yunlong Tan, Yixin Yuan, L. Tian
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Anti-Cosmopolitan Campaign in the USSR: Russian Historiography in 2010s – Early 2020s

open access: yesСибСкрипт
The article describes the recent Russian historiography (2010s – early 2020s) on the anti-cosmopolitan campaign launched by the Soviet authorities in 1949–1953. The research relied on the principles of historicism and objectivity.
Elena S. Genina   +1 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Editorial: (10 years) Water-Energy-Food nexus: Towards knowledge synthesis, action prioritization and revitalization of security debates

open access: yesFrontiers in Water, 2023
Mohammad Al-Saidi   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy