Results 41 to 50 of about 343,210 (289)

CLARIN Concept Registry

, 2015
The CLARIN Concept Registry (clarin.eu/conceptregistry) is the place in the CLARIN Infrastructure where common and shared semantics of, but not limited to, linguistic concepts are defined. This is important to achieve semantic interoperability, and to overcome to a degree the diversity in data structures, either in metadata or linguistic resources ...
Schuurman, Ineke, Windhouwer, Menzo, Ohren, Oddrun, Daniel, Zeman   +3 more
openaire   +4 more sources

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Inference under outcome misclassification in health risk models using a simulation study with a validation dataset

Scientific Reports
Death certificates are commonly used in epidemiological studies investigating the relationship between exposure and health outcomes. It is known that death certificates may misclassify the underlying causes of death, and it is commonly understood that if
Xirui Liu, Stacey L. McComish, Sara C. Howard, Joey Y. Zhou, Sergey Y. Tolmachev   +4 more
doaj   +1 more source

Emergency Medical Services Stroke Care Performance Variability in Michigan: Analysis of a Statewide Linked Stroke Registry

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Emergency medical services (EMS) compliance with recommended prehospital care for patients with acute stroke is inconsistent; however, sources of variability in compliance are not well understood.
J. Adam Oostema, Adrienne Nickles, Zhehui Luo, Mathew J. Reeves   +3 more
doaj   +1 more source

TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries. [PDF]

, 2019
BackgroundComparative, real-life and long-term evidence on the effectiveness and safety of phototherapy and systemic therapy in moderate-to-severe atopic eczema (AE) is limited.
Apfelbacher, CJ, Arents, BWM, Barbarot, S, Bosma, AL, Deleuran, M, Eichenfield, LF, Flohr, C, Gerbens, LAA, International TREAT Registry Taskforce, Irvine, AD, Manca, A, Middelkamp-Hup, MA, Schmitt, J, Spuls, PI, Vermeulen, FM, Vestergaard, C, Wall, D, Weidinger, S   +17 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

EVALUATION OF BETA-ADRENOBLOCKERS TREATMENT IN CARDIOVASCULAR DISEASES COMORBID WITH DIABETES IN OUTPATIENT SETTING

Кардиоваскулярная терапия и профилактика, 2017
2 FSBEIHEI.P. PavlovRyazanskyStateMedicalUniversity. Ryazan,RussiaAim. To evaluate the practice of beta-blockers (BB) usage in cardiovascular disease (CVD) patients with diabetes (DM) in two outpatient registries.Material and methods. Registry PROFILE is
N. A. Komkova, A. V. Zagrebelny, Yu. V. Lukina, M. M. Lukyanov, A. N. Vorobyov, К. G. Pereverzeva, N. P. Kutishenko, N. V. Kiseleva, S. Yu. Martsevich   +8 more
doaj   +1 more source