Results 101 to 110 of about 1,827,733 (269)
Optimal Global Rates of Convergence for Nonparametric Regression
The Annals of Statistics, 1982 Consider a $p$-times differentiable unknown regression function $\theta$ of a $d$-dimensional measurement variable. Let $T(\theta)$ denote a derivative of $\theta$ of order $m$ and set $r = (p - m)/(2p + d)$. Let $\hat{T}_n$ denote an estimator of $T(\theta)$ based on a training sample of size $n$, and let $\| \hat{T}_n - T(\theta)\|_q$ be the usual $L^
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
TBM Net Advance Rate Prediction Model Based on Ridge Regression Analysis
Chengshi guidao jiaotong yanjiu[Objective] Accurate prediction of TBM (tunnel boring machine) net advance rate is of significant reference value for selecting urban tunneling methods, planning construction schedules, and controlling construction costs.
SHI Jian +3 more
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Prognostic Significance of Tumor Regression Rate during Concurrent Chemoradiotherapy in Locally Advanced Cervix Cancer: Analysis by Radiation Phase and Histologic Type. [PDF]
J Clin Med, 2020 Kang JH +12 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Multimodal Regression for Enzyme Turnover Rates Prediction
CoRRThe enzyme turnover rate is a fundamental parameter in enzyme kinetics, reflecting the catalytic efficiency of enzymes. However, enzyme turnover rates remain scarce across most organisms due to the high cost and complexity of experimental measurements.
Bozhen Hu +6 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Rate of Convergence for the Wild Bootstrap in Nonparametric Regression
The Annals of Statistics, 1991 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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