Results 111 to 120 of about 3,930,451 (296)
Determination of Drilling Rate Index Based on Rock Strength Using Regression Analysis [PDF]
Anais da Academia Brasileira de Ciências: Drillability is influenced by many factors, including machine parameters and rock properties. The main machine parameters for drilling include rotational speed, thrust force, torque and flush pressure.
HAYATI YENICE
doaj +2 more sources
Pointwise adaptive estimation for robust and quantile regression
, 2009 A nonparametric procedure for robust regression estimation and for quantile regression is proposed which is completely data-driven and adapts locally to the regularity of the regression function. This is achieved by considering in each point M-estimators
Cuenod, Charles-Andre +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A constrained polynomial regression procedure for estimating the local False Discovery Rate
BMC Bioinformatics, 2007 Background In the context of genomic association studies, for which a large number of statistical tests are performed simultaneously, the local False Discovery Rate (lFDR), which quantifies the evidence of a specific gene association with a clinical or ...
Broët Philippe +2 more
doaj +1 more source
MODELING NITROGEN LOADING RATE TO DELAWARE LAKES USING REGRESSION AND NEURAL NETWORKS [PDF]
The objective of this research was to predict the nitrogen-loading rate to Delaware lakes and streams using regression analysis and neural networks. Both models relate nitrogen-loading rate to cropland, soil type and presence of broiler production. Dummy
Bernard, John C. +3 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Orthogonalized regressors and spurious precision. [PDF]
The exposure of a stock's return to exchange-rate changes is conventionally estimated by regression. Often, the market return is included as an additional regressor.
Sercu, Piet, Vandebroek, Martina
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source