Results 91 to 100 of about 2,020,990 (315)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Testing and Modeling Fuel Regression Rate in a Miniature Hybrid Burner
International Journal of Aerospace Engineering, 2012 Ballistic characterization of an extended group of innovative HTPB-based solid fuel formulations for hybrid rocket propulsion was performed in a lab-scale burner. An optical time-resolved technique was used to assess the quasisteady regression history of
Luciano Fanton +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2008 Hazard regression models and cure rate models can be advantageously used in cancer relative survival analysis. We explored the advantages and limits of these two models in colon cancer and focused on the prognostic impact of the year of diagnosis on ...
Launoy, G. +12 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Post-l1-penalized estimators in high-dimensional linear regression models [PDF]
In this paper we study post-penalized estimators which apply ordinary, unpenalized linear regression to the model selected by first-step penalized estimators, typically LASSO. It is well known that LASSO can estimate the regression function at nearly the
Victor Chernozhukov, Alexandre Belloni
core
Dynamics of Interest Rate Curve by Functional Auto-regression [PDF]
The paper applies methods of functional data analysis – functional auto-regression, principal components and canonical correlations – to the study of the dynamics of interest rate curve.
Alexei Onatski, Slava Kargin
core +2 more sources
Impact Of Couple Protection Rate On Birth Rate : A Stochastic Linear Regression Model
Indian Journal of Community Medicine, 1992 Couple Protection Rate is one of the proximate determinants of fertility : Since fertility is affected by a number of socio-cultural and biological factors, an increase in contraceptives acceptance need not necessarily be associated with a decline in ...
Singh A.S +3 more
doaj
Application of regression tress for prediction of water conduits failure rate
E3S Web of Conferences, 2017 This paper presents the results of predicting the failure rate of water distribution pipes and house connections in a selected city in Poland by means of regression trees. Several regression tree models were built as part of modelling.
Kutyłowska Małgorzata
doaj +1 more source