Results 111 to 120 of about 3,894,475 (297)

Classification with unknown class-conditional label noise on non-compact feature spaces [PDF]

open access: yes, 2019
We investigate the problem of classification in the presence of unknown class-conditional label noise in which the labels observed by the learner have been corrupted with some unknown class dependent probability.
Kaban, Ata, Reeve, Henry W J
core   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Determination of Drilling Rate Index Based on Rock Strength Using Regression Analysis [PDF]

open access: yesAnais da Academia Brasileira de Ciências
: Drillability is influenced by many factors, including machine parameters and rock properties. The main machine parameters for drilling include rotational speed, thrust force, torque and flush pressure.
HAYATI YENICE
doaj   +2 more sources

Convergence rates for pointwise curve estimation with a degenerate design [PDF]

open access: yes, 2006
The nonparametric regression with a random design model is considered. We want to recover the regression function at a point x where the design density is vanishing or exploding. Depending on assumptions on the regression function local regularity and on
Gaiffas, Stéphane
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

A constrained polynomial regression procedure for estimating the local False Discovery Rate

open access: yesBMC Bioinformatics, 2007
Background In the context of genomic association studies, for which a large number of statistical tests are performed simultaneously, the local False Discovery Rate (lFDR), which quantifies the evidence of a specific gene association with a clinical or ...
Broët Philippe   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Difficulties with Regression Analyses of Age-Adjusted Rates

open access: yesBiometrics, 1984
A common type of observational study compares population rates in several regions having differing policies in an effort to assess the effects of those policies. In many studies, particularly in public health and epidemiology, age-adjusted rates are regressed on predictor variables to give a covariance-adjusted estimate of effect; this estimate is ...
P R, Rosenbaum, D B, Rubin
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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