BAYESIAN GEOGRAPHICALLY WEIGHTED REGRESSION DALAM PEMODELAN ANGKA INCIDENCE RATE
Euclid, 2018 Dalam dunia kesehatan angka incidence rate dikenal sebagai angka yang menunjukkan jumlah penderita baru suatu penyakit dalam periode waktu tertentu dibandingkan atas populasi yang beresiko pada periode waktu tersebut.
I Gede Nyoman Mindra Jaya +1 more
doaj
A constrained polynomial regression procedure for estimating the local False Discovery Rate
BMC Bioinformatics, 2007 Background In the context of genomic association studies, for which a large number of statistical tests are performed simultaneously, the local False Discovery Rate (lFDR), which quantifies the evidence of a specific gene association with a clinical or ...
Broët Philippe +2 more
doaj +1 more source
Tumor regression rate, PD-L1 expression, pembrolizumab/nab-paclitaxel-based regimens, squamous cell carcinoma, and comorbidities were independently associated with efficacy of neoadjuvant chemoimmunotherapy in non-small cell lung cancer. [PDF]
Front Oncol, 2022 Hu X +12 more
europepmc +1 more source
The Effect of Exchange Rate and Inflation on Foreign Direct Investment and Its Relationship with Economic Growth in Nigeria [PDF]
, 2011 This study is on the effect of exchange rate and inflation on foreign direct investment and its relationship with economic growth. Its main objective is to find the effect of inflation and exchange rate and the bidirectional influences between FDI and ...
Omankhanlen, A. E
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Prognostic Value of Regression Rate of Plasma EBV DNA After Induction Chemotherapy for Stage II-IVA Nasopharyngeal Carcinoma. [PDF]
Front Oncol, 2021 Peng H, Chen BB, Wang XH, Mo YX, Han F.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Difficulties with Regression Analyses of Age-Adjusted Rates
Biometrics, 1984 A common type of observational study compares population rates in several regions having differing policies in an effort to assess the effects of those policies. In many studies, particularly in public health and epidemiology, age-adjusted rates are regressed on predictor variables to give a covariance-adjusted estimate of effect; this estimate is ...
P R, Rosenbaum, D B, Rubin
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source