Results 61 to 70 of about 804 (216)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
ON Locally Semi Right Invo-Regular Ring
NTU Journal of Pure SciencesAn associative ?i?g ???? with identity is claimed to be locally ????i?ht (le?t) semi invo-Reg. Ring (L.S.I.Reg.Ri?g) , if for every elemen? a in ???? , either a or (1 ? a) is ????ight (le?t) semi involution Reg. elemen?
Yasmine Al Younis, Zubaida Ibraheem
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
NEW FUNDAMENTAL RELATIONS IN HYPERRINGS AND THE CORRESPONDING QUOTIENT STRUCTURES [PDF]
Journal of Algebraic SystemsIn this article, we introduce and analyze the smallest equivalence binary relation $\chi ^{*}$ on a hyperring $R$ such that the quotient $R/\chi ^{*}$, the set of all equivalence classes, is a commutative ring with identity and of ...
Peyman Ghiasvand +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
THE CLEANNESS OF THE SUBRINGS OF M_2 (Z_P)
BarekengLet be a ring. Ring is said to be a clean ring if every element of R can be expressed as the sum of a unit and an idempotent element. Furthermore, there are r-clean rings. An r-clean ring is a generalization of a clean ring.
Shinta Nur Alfiana +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Rings decomposed into direct sums of J-rings and nil rings
International Journal of Mathematics and Mathematical Sciences, 1985 Let R be a ring (not necessarily with identity) and let E denote the set of idempotents of R. We prove that R is a direct sum of a J-ring (every element is a power of itself) and a nil ring if and only if R is strongly π-regular and E is contained in ...
Hisao Tominaga
doaj +1 more source