Results 181 to 190 of about 1,906,383 (319)

Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas. [PDF]

open access: yesCells, 2023
Apicella C   +12 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Behind the scenes: How RNA orchestrates the epigenetic regulation of gene expression. [PDF]

open access: yesFront Cell Dev Biol, 2023
Mangiavacchi A, Morelli G, Orlando V.
europepmc   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Cross-kingdom regulation of gene expression in giant pandas via plant-derived miRNA. [PDF]

open access: yesFront Vet Sci
Tan H   +9 more
europepmc   +1 more source

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