Results 171 to 180 of about 175,401,209 (303)

Multiparent recombinant inbred lines crossed to a tester provide novel insights into sources of cis and trans regulation of gene expression. [PDF]

Genetics
Marroni F, Morse AM, Nanni AV, Nolte N, Williams-Simon P, León-Novelo LG, Graze RM, Schmidt P, King E, McIntyre LM.   +9 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Epigenetic Regulation and Gene Expression Profiles in Cervical Swabs: Toward Non-Invasive Biomarkers of Cervical Lesion Progression. [PDF]

Epigenomes
Kašubová I, Hornáková A, Kotúľová L, Rokos T, Kolková Z, Kapinová A, Pribulová T, Kozubík E, Kalman M, Biringer K, Kúdela E, Holubeková V.   +11 more
europepmc   +1 more source

Plant nuclear envelope as a hub connecting genome organization with regulation of gene expression. [PDF]

Nucleus, 2023
Tang Y.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Dynamic 3D chromatin organization and epigenetic regulation of gene expression in peanut nodules. [PDF]

J Integr Plant Biol
Wang L, Mai C, He S, Niu B, Jia G, Yang T, Xu Y, Ren M, Zhao X, Liu X, Kong Z.   +10 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of gene expression by 5mC DNA methylation during the bolting process of cabbage (<i>Brassica oleracea</i> L. var. <i>capitata</i> L.). [PDF]

Front Plant Sci
Guo H, Chen X, Zhang B, Yao X, Zhuang M, Yang L, Ji J, Wang Y, Lv H, Zhang Y.   +9 more
europepmc   +1 more source

microRNA-dependent regulation of gene expression in GABAergic interneurons. [PDF]

Front Cell Neurosci, 2023
Kołosowska KA, Schratt G, Winterer J.
europepmc   +1 more source