Results 191 to 200 of about 2,700,809 (357)

Insulin Regulation of Glucose-6-phosphate Dehydrogenase Gene Expression Is Rapamycin-sensitive and Requires Phosphatidylinositol 3-Kinase [PDF]

, 1998
Asavari Wagle, Sanjay Jivraj, Ginny Lynn Garlock, Susan Stapleton   +3 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dynamic 3D chromatin organization and epigenetic regulation of gene expression in peanut nodules. [PDF]

J Integr Plant Biol
Wang L, Mai C, He S, Niu B, Jia G, Yang T, Xu Y, Ren M, Zhao X, Liu X, Kong Z.   +10 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Applying the brakes to transcription: regulation of gene expression by RNA polymerase pausing. [PDF]

J Bacteriol
Jayasinghe OT, Babitzke P.
europepmc   +1 more source

Tissue-specific regulation of gene expression via unproductive splicing. [PDF]

Nucleic Acids Res, 2023
Mironov A, Petrova M, Margasyuk S, Vlasenok M, Mironov AA, Skvortsov D, Pervouchine DD.   +6 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Regulation of gene expression through protein-metabolite interactions. [PDF]

NPJ Metab Health Dis
Hornisch M, Piazza I.
europepmc   +1 more source

Translational efficiency in gas-fermenting bacteria: Adding a new layer of regulation to gene expression in acetogens. [PDF]

iScience, 2023
Re A.
europepmc   +1 more source

Non-reciprocal regulation ofRhodobacter capsulatusandRhodobacter sphaeroides recAgenes expression [PDF]

, 1995
Antonio R. Fernández de Henestrosa, E Rivera, Jordi Barbé   +2 more
openalex   +1 more source