Results 41 to 50 of about 1,600,466 (167)
Nature Communications, 2019 Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options.
Nicholas D. Weber +7 more
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Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB
Biomedicines, 2017 Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to the mechanisms controlling cellular responses under such stress stimuli, are the transcription factor families of Hypoxia Inducible Factor (HIF) and Nuclear Factor of
Laura D’Ignazio +2 more
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Hypoxia and the regulation of gene expression
Molecular Medicine Today, 1998 The optimal delivery of oxygen to tissues is essential both to ensure adequate energy provision and to avoid the toxic effects of higher oxygen concentrations. For this to occur, organisms must be able to sense oxygen and respond to changes in oxygen tension by altering gene expression.
Gleadle, J, Ratcliffe, P
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Dualistic role of ZEB1 and ZEB2 in tumor progression
Biology DirectIt is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis.
Sergey E. Parfenyev +6 more
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Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells
eLife, 2015 Previously, we analyzed protein abundance changes across a ‘minimally perturbed’ cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014).
Tony Ly, Aki Endo, Angus I Lamond
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Animal Models of Chronic Hepatitis Delta Virus Infection Host–Virus Immunologic Interactions
Pathogens, 2015 Hepatitis delta virus (HDV) is a defective RNA virus that has an absolute requirement for a virus belonging to the hepadnaviridae family like hepatitis B virus (HBV) for its replication and formation of new virions.
Rafael Aldabe +3 more
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A mouse model for functional dissection of TAB1 O-GlcNAcylation [version 2; peer review: 2 approved]
Wellcome Open Research, 2020 Background: O-GlcNAcylation is a posttranslational modification associated with various physiological and pathophysiological processes including diabetes, cancer, neurodegeneration and inflammation.
Florence Authier +2 more
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Molecular Basis of the Function of Transcriptional Enhancers
Cells, 2020 Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process ...
Airat N. Ibragimov +2 more
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Regulation of Gene Expression by Hypoxia [PDF]
Sleep, 1993 The present study was undertaken to determine if gene expression for tyrosine hydroxylase (TH), the rate limiting enzyme in the biosynthesis of catecholamines, is regulated in the carotid body, sympathetic ganglia and adrenal medulla by hypoxia. We found that a reduction in oxygen tension from 21% to 10% caused a substantial increase (200% at 1 hour ...
Douglas A. Bayliss +3 more
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Evolution of Regulated Transcription
Cells, 2020 The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and ...
Oleg V. Bylino +2 more
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