Results 111 to 120 of about 166,267,164 (196)

Mpox virus OPG175 negatively regulates viral replication by controlling Wnt signaling

iScience
Mpox virus (MPXV) infection exhibits different case fatality rates and symptoms depending on its clade. However, there has been insufficient molecular biological analysis of the differences between clades. Here, we investigated whether clades can be distinguished by focusing on the expression of MPXV genes. The replication efficiency of MPXV clade IIb,
Yoshitaka Nakata, Masako Yamasaki, Yukio Watanabe, Keiya Uriu, Rina Hashimoto, Takuya Yamamoto, Kei Sato, Akatsuki Saito, Kazuo Takayama   +8 more
openaire   +2 more sources

Pestiviruses utilize pyrimidine metabolism to regulate mitophagy for viral replication

Autophagy
DHODH (dihydroorotate dehydrogenase (quinone)) has been demonstrated as a critical regulator of programmed cell death, yet its role in macroautophagy/autophagy remains poorly defined. Flaviviridae pose a significant threat to global public health, and their replication is closely associated with autophagy. Building upon our previous findings that DHODH
Bingqian Zhao, Jing Chen, Yan Cheng, Yuhang Li, Linhan Zhong, Jinxia Chen, Xiaoqing Bi, Jishan Bai, Qi Dai, Yinbo Ye, Linke Zou, Li Wang, Bin Zhou   +12 more
openaire   +1 more source

Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system.

PLoS Pathogens, 2019
Kaposi's sarcoma-associated herpesvirus (KSHV) is causally associated with Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The IFIT family of proteins inhibits replication of some viruses, but their effects on KSHV
Dajiang Li, Sankar Swaminathan
doaj   +1 more source

Two 3′ proximal hairpins play a key role in the replication of wheat yellow mosaic virus

Phytopathology Research
Wheat yellow mosaic virus (WYMV), a member of the genus Bymovirus, causes substantial losses in wheat production in East Asia, including China and Japan.
Guowei Geng, Minjun Liu, Xuefeng Yuan
doaj   +1 more source

An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

Cell Reports
Summary: Upon infection, viruses alter the proteome, creating a hospitable environment for infection. Cells respond to limit viral replication, including through protein regulation by post-translational modifications.
Zachary Walter, Minghua Li, Melissa Molho, Lauren Berish, Andrew Isopi, Mary O’Mara, Mark Dittmar, Chike Nwaezeapu, Alicia Richards, Martin McCullagh, Nevan J. Krogan, Sara Cherry, Jeffrey R. Johnson, Holly Ramage   +13 more
doaj   +1 more source

Viral miRNA delivered by exosomes from Marek's disease virus-transformed lymphoma cell line exerts regulatory function in internalized primary chicken embryo fibroblast cells

Tumour Virus Research
In the past decade, research has demonstrated that viral miRNAs encoded by a number of viral genomes, particularly by most of the herpesvirus including Marek's disease virus (MDV), play important regulatory roles in viral infection, replication, and ...
Man Teng, Jun Luo, Yaoyao Zhang, Vishwanatha R.A.P. Reddy, Priya Samuel, Yongxiu Yao, Venugopal Nair   +6 more
doaj   +1 more source

Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate

Viruses
The host enzyme heparanase (HPSE) facilitates the release of herpes simplex virus type 2 (HSV-2) from target cells by cleaving the viral attachment receptor heparan sulfate (HS) from infected cell surfaces.
James Hopkins, Ipsita Volety, Farreh Qatanani, Deepak Shukla   +3 more
doaj   +1 more source

Defective interfering particles of parainfluenza virus subtype 5 and interferon induction [PDF]

, 2015
The innate immune response is the first line of defence against virus infection. Cells contain a diverse array of pathogen recognition receptors (PRRs) that are able to recognise multiple pathogen associated molecular patterns (PAMPS) that present ...
Short, John A. L.
core   +1 more source

Essential function of the integrator complex in Kaposi’s sarcoma-associated herpesvirus lytic replication

Journal of Virology
The integrator complex (INT) is an essential regulator of RNA biogenesis across evolution. Most current findings describe INT’s function in states of equilibrium, presenting a research gap in INT’s role in dynamic states, such as in infections and ...
Amy Nguyen, Tianqi Li, Conner Traugot, Kimberly Paulsen, Tiffany S. Nelson, Mingyi Xie, Zhe Ma   +6 more
doaj   +1 more source

FBXO45 restricts HIV-1 replication by inducing SQSTM1/p62-mediated autophagic degradation of Tat

Journal of Virology
As a key regulator of human immunodeficiency virus type 1 (HIV-1) transcription, Tat plays an essential role in viral replication and latency, making it a promising target for designing viral control strategies. Identifying host factors that modulate Tat
Mingxiu Xu, Haobo Hu, Weijing Yang, Jiaxiang Zhang, Hong Wang, Wenyan Zhang, Chen Huan   +6 more
doaj   +1 more source