Results 91 to 100 of about 166,267,164 (196)

Annexin A1 negatively regulates viral RNA replication of hepatitis C virus.

Acta medica Okayama, 2015
Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies.
Hiramoto, Hiroki, Dansako, Hiromichi, Takeda, Midori, Satoh, Shinya, Wakita, Takaji, Ikeda, Masanori, Kato, Nobuyuki   +6 more
openaire   +3 more sources

De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]

, 2009
The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Sawtell, N.M., Thompson, R.L., Richard L Thompson, Chris M Preston, Nancy M Sawtell, Preston, C.M.   +5 more
core   +1 more source

Viral and host factors regulating influenza virus replication

, 2017
Avian influenza A viruses typically do not replicate very efficiently when exposed to a mammalian host species. One of the reasons for this is the low activity of the viral RNA-dependent RNA polymerase of avian influenza viruses in mammalian cells. This host restrictive effect can be overcome by adaptive mutations in the avian polymerase, many of which
openaire   +1 more source

A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication [PDF]

, 2011
DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Di Cicco, Giulia, Maga, Giovanni, Giulia Di Cicco, Anna Garbelli, Beermann, Sandra, Dietrich, Ursula, Giovanni Maga, Ursula Dietrich, Sandra Beermann, Garbelli, Anna   +9 more
core   +1 more source

Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis

PLOS Pathogens, 2018
Replication of positive-strand RNA viruses [(+)RNA viruses] takes place in membrane-bound viral replication complexes (VRCs). Formation of VRCs requires virus-mediated manipulation of cellular lipid synthesis. Here, we report significantly enhanced brome mosaic virus (BMV) replication and much improved cell growth in yeast cells lacking PAH1 (pah1Δ ...
Zhenlu Zhang, Guijuan He, Gil-Soo Han, Jiantao Zhang, Nicholas Catanzaro, Arturo Diaz, Zujian Wu, George M. Carman, Lianhui Xie, Xiaofeng Wang   +9 more
openaire   +4 more sources

Cytomegalovirus microRNAs facilitate persistent virus infection in salivary glands. [PDF]

, 2010
Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability.
Marcinowski, Lisa, Lars Dölken, Astrid Krmpotic, Jonjic, S. (Stipan), Kothe, Sheila, Ruzsics, Zsolt, Tanguy Mélanie, Koszinowski, Ulrich H, Dölken Lars, Krmpotic Astrid, Zsolt Ruzsics, Ruzsics, Z. (Zsolt), Tuddenham, L. (Lee), Jonjic Stipan, Elefant, N. (Naama), Tanguy, Mélanie, Elefant Naama, Pfeffer, S. (Sebastien), Koszinowski, U. (Ulrich H), Marcinowski Lisa, Lisa Marcinowski, Elefant, Naama, Ulrich H Koszinowski, Tuddenham Lee, Altuvia, Yael, Koszinowski Ulrich H., Lee Tuddenham, Stipan Jonjic, Pfeffer Sébastien, Altuvia, Y. (Yael), Kothe Sheila, Sébastien Pfeffer, Tuddenham, Lee, Mélanie Tanguy, Margalit, Hanah, Ruzsics Zsolt, Margalit Hanah, Marcinowski, L. (Lisa), Krmpotic, A. (Astrid), Koszinowski, Ulrich H., Dölken, L. (Lars), Tanguy, M. (Mélanie), Krmpotic, Astrid, Sheila Kothe, Dölken, Lars, Ulrich H. Koszinowski, Yael Altuvia, Naama Elefant, Pfeffer, Sébastien, Kothe, S. (Sheila), Hanah Margalit, Altuvia Yael, Jonjic, Stipan, Margalit, H. (Hanah)   +53 more
core   +1 more source

Molecular biology of giant viruses' DNA replication machinery [PDF]

, 2013
Viruses are the most widespread and abundant entity on this planet, further constituting the largest part of the genosphere. The majority of these infectious agents are miniature, having been described as being smaller than the smallest bacteria.
Evripioti, Antonia Alexandra
core   +2 more sources

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants [PDF]

, 2010
Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease ...
Stefan Zeuzem, Randle, John C. R., Randle John C. R., Lin, Chao, Kwong Ann D., Bambang S Adiwijaya, John C. R. Randle, Sarrazin, Christoph, Paul R. Caron, Herrmann Eva, Zeuzem Stefan, Christoph Sarrazin, Garg Varun, Kieffer, Tara, Brian Hare, Hare, Brian, Varun Garg, Lin Chao, Kieffer Tara, Herrmann, Eva, Caron, Paul R., Kwong, Ann D., Tara Kieffer, Ann D Kwong, Sarrazin Christoph, Chao Lin, Bambang S. Adiwijaya, Adiwijaya, Bambang S., Hare Brian, Paul R Caron, Caron Paul R., Garg, Varun, Eva Herrmann, Ann D. Kwong, John C R Randle, Adiwijaya Bambang S., Zeuzem, Stefan   +36 more
core   +2 more sources

The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A.

PLoS Pathogens, 2013
The lipid kinase phosphatidylinositol 4-kinase III alpha (PI4KIIIα) is an essential host factor of hepatitis C virus (HCV) replication. PI4KIIIα catalyzes the synthesis of phosphatidylinositol 4-phosphate (PI4P) accumulating in HCV replicating cells due ...
Simon Reiss, Christian Harak, Inés Romero-Brey, Danijela Radujkovic, Rahel Klein, Alessia Ruggieri, Ilka Rebhan, Ralf Bartenschlager, Volker Lohmann   +8 more
doaj   +1 more source

Raf‐1 kinase associates with Hepatitis C virus NS5A and regulates viral replication

FEBS Letters, 2005
Hepatitis C virus (HCV) is a positive‐strand RNA virus that frequently causes persistent infection associated with severe liver disease. HCV nonstructural protein 5A (NS5A) is essential for viral replication. Here, the kinase Raf‐1 was identified as a novel cellular binding partner of NS5A, binding to the C‐terminal domain of NS5A.
Bürckstümmer, Tilmann, Kriegs, Malte, Lupberger, Joachim, Pauli, Eva-K., Schmittel, S., Hildt, Eberhardt   +5 more
openaire   +3 more sources