Results 71 to 80 of about 166,267,164 (196)

Viral Replication Regulated by Radiation

Viruses are widely present in nature and can infect eukaryotic cells, producing a variety of biological effects. Several viruses are capable of coexisting with human cells over the long term, and it has been proven that these viruses possess carcinogenic properties. Radiation therapy is a common method used for treating tumors.
Yu Zhao, Yingyi Zhang, Yang Liu, Junling Zhang, Sen Wang, Danyue Qu, Xinyuan Ji, Saijun Fan   +7 more
openaire   +1 more source

Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses

Viruses, 2019
Typical viral propagation involves sequential viral entry, uncoating, replication, gene transcription and protein synthesis, and virion assembly and release. Some viral proteins must be transported into host nucleus to facilitate viral propagation, which
Guohui Li, Xinyu Qi, Zhaoyang Hu, Qi Tang   +3 more
doaj   +1 more source

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication [PDF]

, 2014
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA ...
Atkinson, N J, Simmonds, Peter, Atkinson, Nicky J., Evans, David J., Witteveldt, Jeroen, Evans, D. J.   +5 more
core   +1 more source

The targeted cytosolic degradation of class I histone deacetylases is essential for efficient alphaherpesvirus replication

eLife
Viral infection triggers a robust DNA damage response (DDR), reshaping the host chromatin landscape to facilitate viral replication. Here, we uncover a novel mechanism by which alphaherpesviruses exploit the DDR pathway.
Sheng-Li Ming, Meng-Hua Du, Jia-Ming Yang, Ya-Di Guo, Jia-Jia Pan, Wei-Fei Lu, Jiang Wang, Lei Zeng, Bei-Bei Chu   +8 more
doaj   +1 more source

Nuclear Factor 90 Negatively Regulates Influenza Virus Replication by Interacting with Viral Nucleoprotein [PDF]

Journal of Virology, 2009
ABSTRACTInteractions between host factors and the viral replication complex play important roles in host adaptation and regulation of influenza virus replication. A cellular protein, nuclear factor 90 (NF90), was copurified with H5N1 viral nucleoprotein (NP) from human cells in which NP was transiently expressed and identified by matrix-assisted laser ...
Wang, Pui, Song, Wenjun, Mok, Bobo Wing-Yee, Zhao, Pengxi, Qin, Kun, Lai, Alexander, Smith, Gavin J. D., Zhang, Jinxia, Guan, Yi, Chen, Honglin, Lin, Tianwei   +10 more
openaire   +4 more sources

Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor [PDF]

, 1994
We have shown previously that the antiviral function of CD4+ T lymphocytes against murine cytomegalovirus (MCMV) is associated with the release of interferon- (IFN-).
Koszinowski, Ulrich H., Lucin, Pero, Messerle, Martin, Polic, Bojan, Jonjic, Stipan, Hengel, Hartmut   +5 more
core  

The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene. [PDF]

PLoS ONE, 2010
Human cytomegalovirus (HCMV) can be reactivated under immunosuppressive conditions causing several fatal pneumonitis, hepatitis, retinitis, and gastrointestinal diseases. HCMV also causes deafness and mental retardation in neonates when primary infection
Hiroki Isomura, Mark F Stinski, Takayuki Murata, Sanae Nakayama, Shigeki Chiba, Yoshiki Akatsuka, Teru Kanda, Tatsuya Tsurumi   +7 more
doaj   +1 more source

Interferon-Alpha Mediates Restriction of Human Immunodeficiency Virus Type-1 Replication in Primary Human Macrophages at an Early Stage of Replication [PDF]

, 2010
Type I interferons (IFNα and β) are induced directly in response to viral infection, resulting in an antiviral state for the cell. In vitro studies have shown that IFNα is a potent inhibitor of viral replication; however, its role in HIV-1 infection is ...
McKnight, A, McKnight Áine, Cheney, KM, Kelly M Cheney, Áine McKnight, Cheney Kelly M.   +5 more
core   +2 more sources

Dual Interaction of a Geminivirus Replication Accessory Factor with a Viral Replication Protein and a Plant Cell Cycle Regulator

Virology, 2001
Geminiviruses replicate their small, single-stranded DNA genomes through double-stranded DNA intermediates in plant nuclei using host replication machinery. Like most dicot-infecting geminiviruses, tomato golden mosaic virus encodes a protein, AL3 or C3, that greatly enhances viral DNA accumulation through an unknown mechanism.
Settlage, Sharon B., Miller, Ann B., Gruissem, Wilhelm, Hanley-Bowdoin, Linda   +3 more
openaire   +2 more sources

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]

, 2002
Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Ruiz, L, Javier Martinez-Picado, Clotet, B, Frost, SDW, Martinez-Picado, J, Lidia Ruiz, Leigh Brown, AJ, Simon D. W. Frost, Bonaventura Clotet, Andrew J. Leigh Brown   +9 more
core   +1 more source