Results 51 to 60 of about 166,267,164 (196)

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail [PDF]

, 2015
A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms
Struthers, M, Tuplin, AK, Tuplin, Andrew, Bentley, K, Struthers, Madeleine, Cook, J, Cook, Jonathan, Evans, DJ, Evans, David J., Struthers, Madeline, Bentley, Kirsten, Cook, Jonathan P.   +11 more
core   +1 more source

Liver-Derived Cell Transfection Model Efficacy for HBV Genotype B Replication/Transcription Is Determined by Complex Host Transcription Factor Network

Viruses, 2021
Background: Interaction between host transcription factors (TFs) and the viral genome is fundamental for hepatitis B virus (HBV) gene expression regulation.
Roxanne Hui-Heng Chong, Atefeh Khakpoor, Theresa May-Chin Tan, Seng-Gee Lim, Guan-Huei Lee   +4 more
doaj   +1 more source

PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication

Journal of Virology, 2022
M1 is proposed to play multiple biologically important roles in the life cycle of IAV, which relies largely on host factors. This study is the first one to identify that PSMD12 interacts with M1, mediates K63-linked ubiquitination of M1 at the K102 site, and thus positively regulates influenza virus proliferation.
Xianfeng Hui, Lei Cao, Ting Xu, Lianzhong Zhao, Kun Huang, Zhong Zou, Peilei Ren, Haiying Mao, Ying Yang, Shuo Gao, Xiaomei Sun, Xian Lin, Meilin Jin   +12 more
openaire   +2 more sources

Coalescence of the sites of cowpea mosaic virus RNA replication into a cytopathic structure [PDF]

, 2002
Cowpea mosaic virus (CPMV) replication induces an extensive proliferation of endoplasmic reticulum (ER) membranes, leading to the formation of small membranous vesicles where viral RNA replication takes place.
Carette, J.E., Gühl, K., Wellink, J., Kammen, A., van   +3 more
core   +1 more source

Metabolic interference impairs influenza A virus replication by dampening vRNA synthesis

npj Viruses
For replication, viruses exploit the host cell metabolism for biosynthesis of viral components. Recently, we could show that inhibition of glycolysis interfered with IAV replication by impairing the regulation of the viral polymerase as a transcriptase ...
Jens Kleinehr, Chiara Robin Bojarzyn, Michael Schöfbänker, Katharina Daniel, Stephan Ludwig, Eike R. Hrincius   +5 more
doaj   +1 more source

Persistence of an Oncogenic Papillomavirus Genome Requires cis Elements from the Viral Transcriptional Enhancer

mBio, 2017
Human papillomavirus (HPV) genomes are replicated and maintained as extrachromosomal plasmids during persistent infection. The viral E2 proteins are thought to promote stable maintenance replication by tethering the viral DNA to host chromatin.
Koenraad Van Doorslaer, Dan Chen, Sandra Chapman, Jameela Khan, Alison A. McBride   +4 more
doaj   +1 more source

The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. [PDF]

, 2011
The influenza A virus RNA polymerase is a heterotrimeric complex responsible for viral genome transcription and replication in the nucleus of infected cells. We recently carried out a proteomic analysis of purified polymerase expressed in human cells and
Juan Ortín, Landeras-Bueno, Sara, Jorba, N, Sara Landeras-Bueno, Ortín Juan, Pérez-Cidoncha, Maite, Pérez-Cidoncha, M, Núria Jorba, Landeras-Bueno Sara, Pérez-Cidoncha Maite, Landeras-Bueno, S, Ortín, J, Ortín, Juan, Jorba, Núria, Maite Pérez-Cidoncha, Jorba Núria   +15 more
core   +2 more sources

TRIM21 Restricts Coxsackievirus B3 Replication, Cardiac and Pancreatic Injury via Interacting With MAVS and Positively Regulating IRF3-Mediated Type-I Interferon Production

Frontiers in Immunology, 2018
Tripartite motif-containing 21 (TRIM21) is a regulator of tissue inflammation and pro-inflammatory cytokine production, and has been implicated in negative regulation of IRF3-dependent type I interferon signaling.
Hui Liu, Min Li, Yahui Song, Wei Xu
doaj   +1 more source

Tuning Rex rules HTLV-1 pathogenesis

Frontiers in Immunology, 2022
HTLV-1 is an oncovirus causing ATL and other inflammatory diseases such as HAM/TSP and HU in about 5% of infected individuals. It is also known that HTLV-1-infected cells maintain a disease-free, immortalized, latent state throughout the lifetimes of ...
Kazumi Nakano, Toshiki Watanabe
doaj   +1 more source

Licochalcone A regulates viral IRES activity to inhibit enterovirus replication

Antiviral Research
Enterovirus D68 (EV-D68), belonging to the genus Enterovirus of the Picornavirus family, is an emerging pathogen that can cause neurological and respiratory diseases in children. However, there is little understanding of the pathogenesis of EV-D68, and no effective vaccine or drug for the prevention or treatment of the diseases caused by this virus is ...
Yu-Ting Chuang, Yu-Li Lin, Jing-Yi Lin
openaire   +2 more sources