Results 31 to 40 of about 186,764 (256)
PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication
Journal of Virology, 2022 M1 is proposed to play multiple biologically important roles in the life cycle of IAV, which relies largely on host factors. This study is the first one to identify that PSMD12 interacts with M1, mediates K63-linked ubiquitination of M1 at the K102 site, and thus positively regulates influenza virus proliferation.
Xianfeng Hui +12 more
openaire +2 more sources
PLoS ONE, 2019 The E1B 55kDa produced by human adenovirus type 5 is a multifunctional protein that participates in the regulation of several steps during the viral replication cycle.
Berto Tejera +12 more
doaj +1 more source
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication.
PLoS Pathogens, 2012 Merkel cell polyomavirus (MCV or MCPyV) is the first human polyomavirus to be definitively linked to cancer. The mechanisms of MCV-induced oncogenesis and much of MCV biology are largely unexplored.
Xin Wang +5 more
doaj +1 more source
Synthetic Tumor-Specific Promoters for Transcriptional Regulation of Viral Replication
, 2017 Here we describe a collection of methods that have been adapted to isolate and modify tumor-specific promoters (TSPs ) to drive viral replication for cancer therapy and other uses. We will describe as examples the secreted protein acidic and rich in cysteine (SPARC ) and the protease-activated receptor-1 (PAR-1) promoter.
Lopez, Maria Veronica +3 more
openaire +4 more sources
Leader RNA regulates snakehead vesiculovirus replication via interacting with viral nucleoprotein [PDF]
RNA Biology, 2020 Leader RNA, a kind of virus-derived small noncoding RNA, has been proposed to play an important role in regulating virus replication, but the underlying mechanism remains elusive. In this study, snakehead vesiculovirus (SHVV), a kind of fish rhabdovirus causing high mortality to the cultured snakehead fish in China, was used to unveil the molecular ...
Xiangmou Qin +6 more
openaire +2 more sources
Stearoyl Coenzyme A Desaturase 1 Is Associated with Hepatitis C Virus Replication Complex and Regulates Viral Replication [PDF]
Journal of Virology, 2014 ABSTRACT The hepatitis C virus (HCV) life cycle is tightly regulated by lipid metabolism of host cells. In order to identify host factors involved in HCV propagation, we have recently screened a small interfering RNA (siRNA) library targeting host genes that control lipid metabolism and lipid droplet formation using cell culture-grown HCV ...
Nguyen, LN +5 more
openaire +3 more sources
Scientifica, 2014 Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections.
Madhuvanthi Vijayan, Bumsuk Hahm
doaj +1 more source
Viruses, 2021 Background: Interaction between host transcription factors (TFs) and the viral genome is fundamental for hepatitis B virus (HBV) gene expression regulation.
Roxanne Hui-Heng Chong +4 more
doaj +1 more source
Metabolic interference impairs influenza A virus replication by dampening vRNA synthesis
npj VirusesFor replication, viruses exploit the host cell metabolism for biosynthesis of viral components. Recently, we could show that inhibition of glycolysis interfered with IAV replication by impairing the regulation of the viral polymerase as a transcriptase ...
Jens Kleinehr +5 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source