Results 31 to 40 of about 183,339 (262)
Veterinary Research, 2021 Elucidating virus-cell interactions is fundamental to understanding viral replication and identifying targets for therapeutic control of viral infection.
Huan Wang +9 more
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HIV-1 gene expression: lessons from provirus and non-integrated DNA
Retrovirology, 2004 Replication of HIV-1 involves a series of obligatory steps such as reverse transcription of the viral RNA genome into double-stranded DNA, and subsequent integration of the DNA into the human chromatin.
Wu Yuntao
doaj +1 more source
Synthetic Tumor-Specific Promoters for Transcriptional Regulation of Viral Replication
, 2017 Here we describe a collection of methods that have been adapted to isolate and modify tumor-specific promoters (TSPs ) to drive viral replication for cancer therapy and other uses. We will describe as examples the secreted protein acidic and rich in cysteine (SPARC ) and the protease-activated receptor-1 (PAR-1) promoter.
Lopez, Maria Veronica +3 more
openaire +4 more sources
Human cytomegalovirus miR‐US33‐5p inhibits viral DNA synthesis and viral replication by down‐regulating expression of the host Syntaxin3 [PDF]
FEBS Letters, 2015 During infection with human cytomegalovirus (HCMV), overexpression of hcmv‐miR‐US33 can inhibit the lytic viral replication and down‐regulate US29 mRNA. However, it remains unknown whether inhibition of viral replication by miR‐US33 is mediated by down‐regulation of expression of US29 or another host gene.
Guo, Xin +8 more
openaire +2 more sources
Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication.
PLoS Pathogens, 2012 Merkel cell polyomavirus (MCV or MCPyV) is the first human polyomavirus to be definitively linked to cancer. The mechanisms of MCV-induced oncogenesis and much of MCV biology are largely unexplored.
Xin Wang +5 more
doaj +1 more source
Virology, 2007 Previous genome-wide screens identified over 100 host genes whose deletion/down-regulation affected tombusvirus replication and 32 host genes that affected tombusvirus RNA recombination in yeast, a model host for replication of Tomato bushy stunt virus (TBSV).
Jaag, Hannah M. +2 more
openaire +2 more sources
PLoS ONE, 2019 The E1B 55kDa produced by human adenovirus type 5 is a multifunctional protein that participates in the regulation of several steps during the viral replication cycle.
Berto Tejera +12 more
doaj +1 more source
Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication
Virulence, 2022 Numerous viruses manipulate host factors for viral production. We demonstrated that human enterovirus A71 (EVA71), a primary causative agent for hand, foot, and mouth disease (HFMD), increased the level of the DNA damage response (DDR) marker γ-H2AX. DDR is primarily mediated by the ataxia telangiectasia mutated (ATM), ATM and Rad3-related (ATR), or ...
Jinghua Yu +14 more
openaire +3 more sources
Scientifica, 2014 Viruses attempt to create a distinctive cellular environment to favor viral replication and spread. Recent studies uncovered new functions of the sphingolipid signaling/metabolism during pathogenic virus infections.
Madhuvanthi Vijayan, Bumsuk Hahm
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Viruses, 2021 Background: Interaction between host transcription factors (TFs) and the viral genome is fundamental for hepatitis B virus (HBV) gene expression regulation.
Roxanne Hui-Heng Chong +4 more
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