Reactivation and Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus: An Update
Frontiers in Microbiology, 2017 The life cycle of Kaposi’s sarcoma-associated herpesvirus (KSHV) consists of two phases, latent and lytic. The virus establishes latency as a strategy for avoiding host immune surveillance and fusing symbiotically with the host for lifetime persistent ...
Yan Yuan, Kawalpreet K. Aneja
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IFN-Gamma Inhibits JC Virus Replication in Glial Cells by Suppressing T-Antigen Expression. [PDF]
PLoS ONE, 2015 Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing progressive ...
Francesca Isabella De-Simone +6 more
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TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro
Frontiers in Microbiology, 2023 TMP269, a small molecular inhibitor of IIa histone deacetylase, plays a vital role in cancer therapeutic. However, the effect of TMP269 on the regulation of viral replication has not been studied.
Juanbin Yin +8 more
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Influenza-Induced Innate Immunity: Regulators of Viral Replication, Respiratory Tract Pathology & Adaptive Immunity [PDF]
Future Virology, 2011 Influenza virus infections usually cause mild to moderately severe respiratory disease, however some infections, like those involving the avian H5N1 virus, can cause massive viral pneumonia, systemic disease and death. The innate immune response of respiratory tract resident cells is the first line of defense and limits virus replication.
Karen L, Oslund, Nicole, Baumgarth
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Regulation of Human Papillomavirus Type 1 Replication by the Viral E2 Protein
Virology, 2001 The E1 and E2 proteins encoded by papillomaviruses are required for viral replication. Earlier studies have shown that the viral E2 protein plays an important role in replication by targeting the E1 helicase to the origin of replication (ori). We have previously shown that the E1 protein of human papillomavirus (HPV) type 1 is sufficient for the in ...
Van Horn, Gerald +2 more
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Regulation of simian virus 40 early and late gene transcription without viral DNA replication [PDF]
Journal of Virology, 1979 Primary cultures of African green monkey kidney cells were infected with the simian virus 40 temperature-sensitive mutant tsA58 at the nonpermissive temperature of 41 degrees C for 12 to 20 h. Under these conditions, a defective T antigen was produced and no viral DNA replication was detected.
Birkenmeier, E H +4 more
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TRIM62 From Chicken as a Negative Regulator of Reticuloendotheliosis Virus Replication
Frontiers in Veterinary Science, 2020 Emerging evidence suggests that the tripartite motif containing 62 (TRIM62), a member of the TRIM family, plays an important role in antiviral processes.
Ling Li +6 more
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Hepatocyte nuclear factor 1α downregulates HBV gene expression and replication by activating the NF-κB signaling pathway. [PDF]
PLoS ONE, 2017 The role of hepatocyte nuclear factor 1α (HNF1α) in the regulation of gene expression and replication of hepatitis B virus (HBV) is not fully understood.
Junyu Lin +8 more
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Microbiology Spectrum, 2021 Upon Kaposi’s Sarcoma-associated herpesvirus (KSHV) lytic reactivation, rapid and widespread amplification of viral DNA (vDNA) triggers significant nuclear reorganization.
D. Hoffman +4 more
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The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication [PDF]
Protein & Cell, 2021 AbstractRice stripe virus (RSV) transmitted by the small brown planthopper causes severe rice yield losses in Asian countries. Although viral nuclear entry promotes viral replication in host cells, whether this phenomenon occurs in vector cells remains unknown.
Zhao, Wan +8 more
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