Results 11 to 20 of about 166,267,164 (196)

An Insect Virus-Encoded MicroRNA Regulates Viral Replication [PDF]

Journal of Virology, 2008
ABSTRACT MicroRNAs (miRNAs) are small (∼22 nucleotides) noncoding RNAs which play an essential role in gene regulation and affect a wide range of processes, including development, differentiation, and oncogenesis. Here we report the identification of the first miRNA from an insect virus, derived from the major capsid protein (MCP)
Hussain, Mazhar, Taft, Ryan J., Asgari, Sassan   +2 more
openaire   +5 more sources

Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication [PDF]

PLOS Pathogens, 2020
Viruses are known for their extremely compact genomes composed almost entirely of protein-coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human cytomegalovirus (HCMV). Although these RNAs accumulate to high levels during lytic infection, their functions remain largely unknown.
Julie Tai-Schmiedel, Sharon Karniely, Betty Lau, Adi Ezra, Erez Eliyahu, Aharon Nachshon, Karen Kerr, Nicolás Suárez, Michal Schwartz, Andrew J. Davison, Noam Stern-Ginossar   +10 more
openaire   +4 more sources

Identification of adenovirus E1A gene regions involved in chemosensitisation of prostate cancer cells [PDF]

, 2009
PhDReplication-selective adenoviruses are promising anti-cancer therapies (virotherapy). Viruses can be engineered to selectively target cancer cells by deleting viral genes involved in cell cycle regulation.
Rota, Enrique Miranda
core   +4 more sources

Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses

Viruses, 2020
The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
José L. Martínez, Carlos F. Arias
doaj   +1 more source

Unravelling the structure of viral replication complexes at super-resolution [PDF]

, 2013
This work was supported by Biotechnology and Biomedical Sciences Research Council grant BB/H018719/1During infection, many RNA viruses produce characteristic inclusion bodies that contain both viral and host components.
Karl J. Oparka, Tilsner, Jens, Jens eTilsner, Johannes Liesche, Johannes eLiesche, Olga Linnik, Liesche, Johannes, Olga eLinnik, Karl eOparka, Oparka, Karl J, Jens Tilsner, Oparka, Karl J., Linnik, Olga   +12 more
core   +1 more source

Cellular and Viral Factors Regulate the Varicella-Zoster Virus gE Promoter during Viral Replication [PDF]

Journal of Virology, 2007
ABSTRACT Varicella-zoster virus (VZV) glycoprotein E (gE) is essential for viral replication and is involved in cell-to-cell spread, secondary envelopment, and entry. We created a set of mutations in the gE promoter to investigate the role of viral and cellular transcriptional factors in regulation of the gE promoter.
Barbara, Berarducci, Marvin, Sommer, Leigh, Zerboni, Jaya, Rajamani, Ann M, Arvin   +4 more
openaire   +2 more sources

Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]

, 2011
Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Yule Liu, Bruce, Gareth, Bruce Gareth, Liu, Yule, Liu Yule, Gareth Bruce, Nongnong Shi, Gu, Mei, Hong, Yiguo, Shi Nongnong, Yiguo Hong, Gu Mei, Shi, Nongnong, Hong Yiguo, Mei Gu   +14 more
core   +1 more source

Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication

Viruses, 2014
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
doaj   +1 more source

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo [PDF]

, 2011
There is increasing evidence for a connection between DNA replication and the expression of adjacent genes. Therefore, this study addressed the question of whether a herpesvirus origin of replication can be used to activate or increase the expression of ...
Mohr, Hermine, Eckhard Wolf, Marlon R. Schneider (160130), Ulrich H Koszinowski, Laura Scrivano (160134), Eckhard Wolf (39870), Koszinowski Ulrich H., Ruzsics, Zsolt, Schnieke Angelika, Christian A. Mohr (160123), Ulrich H. Koszinowski (152143), Marlon R. Schneider, Mohr Hermine, Schneider Marlon R., Dahlhoff, Maik, Hermine Mohr (160119), Zsolt Ruzsics (75383), Simone Kraner-Schreiber, Schneider, Marlon R., Christian A Mohr, Laura Scrivano, Kraner-Schreiber, Simone, Maik Dahlhoff, Simone Kraner-Schreiber (160141), Ruzsics Zsolt, Maik Dahlhoff (160144), Adler Barbara, Koszinowski, Ulrich H., Kraner-Scheiber, Simone, Zsolt Ruzsics, Mohr, Christian A., Kraner-Schreiber Simone, Schnieke, Angelika, Adler, Barbara, Wolf Eckhard, Dahlhoff Maik, Barbara Adler, Ulrich H. Koszinowski, Christian A. Mohr, Mohr Christian A., Scrivano Laura, Wolf, Eckhard, Hermine Mohr, Marlon R Schneider, Scrivano, Laura, Angelika Schnieke (133290), Barbara Adler (160138), Angelika Schnieke   +47 more
core   +2 more sources

Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells [PDF]

, 2009
This work was supported by the Wellcome Trust.Although the replication cycle of parainfluenza virus type 5 (PIV5) is initially severely impaired in cells in an interferon (IFN)-induced antiviral state, the virus still targets STAT1 for degradation.
Carlos, T S, Schneider, M, Simas, J P, Randall, Richard Edward, Young, Dan Frushard   +4 more
core   +1 more source