Results 11 to 20 of about 186,764 (256)
An Insect Virus-Encoded MicroRNA Regulates Viral Replication [PDF]
Journal of Virology, 2008 ABSTRACT MicroRNAs (miRNAs) are small (∼22 nucleotides) noncoding RNAs which play an essential role in gene regulation and affect a wide range of processes, including development, differentiation, and oncogenesis. Here we report the identification of the first miRNA from an insect virus, derived from the major capsid protein (MCP)
Hussain, Mazhar +2 more
openaire +5 more sources
Human cytomegalovirus long noncoding RNA4.9 regulates viral DNA replication [PDF]
PLOS Pathogens, 2020 Viruses are known for their extremely compact genomes composed almost entirely of protein-coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human cytomegalovirus (HCMV). Although these RNAs accumulate to high levels during lytic infection, their functions remain largely unknown.
Julie Tai-Schmiedel +10 more
openaire +4 more sources
Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses
Viruses, 2020 The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
José L. Martínez, Carlos F. Arias
doaj +1 more source
Cellular and Viral Factors Regulate the Varicella-Zoster Virus gE Promoter during Viral Replication [PDF]
Journal of Virology, 2007 ABSTRACT Varicella-zoster virus (VZV) glycoprotein E (gE) is essential for viral replication and is involved in cell-to-cell spread, secondary envelopment, and entry. We created a set of mutations in the gE promoter to investigate the role of viral and cellular transcriptional factors in regulation of the gE promoter.
Barbara, Berarducci +4 more
openaire +2 more sources
Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication
Viruses, 2014 UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
doaj +1 more source
Molecular components of the circadian clock regulate HIV-1 replication
iScience, 2023 Summary: Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism’s response to its environment and ...
Helene Borrmann +11 more
doaj +1 more source
Cholesterol biosynthesis modulation regulates dengue viral replication
Virology, 2009 We performed a focused siRNA screen in an A549 dengue type 2 New Guinea C subgenomic replicon cell line (Rluc-replicon) that contains a Renilla luciferase cassette. We found that siRNA mediated knock down of mevalonate diphospho decarboxylase (MVD) inhibited viral replication of the Rluc-replicon and DEN-2 NGC live virus replication in A549 cells. When
Rothwell, Christopher +8 more
openaire +2 more sources
Molecular Systems Biology, 2010 The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded
Christopher M Owens +7 more
doaj +1 more source
Reactivation and Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus: An Update
Frontiers in Microbiology, 2017 The life cycle of Kaposi’s sarcoma-associated herpesvirus (KSHV) consists of two phases, latent and lytic. The virus establishes latency as a strategy for avoiding host immune surveillance and fusing symbiotically with the host for lifetime persistent ...
Yan Yuan, Kawalpreet K. Aneja
doaj +1 more source
IFN-Gamma Inhibits JC Virus Replication in Glial Cells by Suppressing T-Antigen Expression. [PDF]
PLoS ONE, 2015 Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing progressive ...
Francesca Isabella De-Simone +6 more
doaj +1 more source