Results 11 to 20 of about 183,339 (262)

Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA [PDF]

Nature Cell Biology, 2010
Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally linked to several acquired immune deficiency syndrome related malignancies including Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentric Castleman’s disease1. Control of viral lytic replication is essential for KSHV latency, evasion of host immune system, and ...
Lei, Xiufen, Bai, Zhiqiang, Ye, Fengchun, Xie, Jianping, Kim, Chan-Gil, Huang, Yufei, Gao, Shou-Jiang   +6 more
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PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication

Journal of Virology, 2022
M1 is proposed to play multiple biologically important roles in the life cycle of IAV, which relies largely on host factors. This study is the first one to identify that PSMD12 interacts with M1, mediates K63-linked ubiquitination of M1 at the K102 site, and thus positively regulates influenza virus proliferation.
Xianfeng Hui, Lei Cao, Ting Xu, Lianzhong Zhao, Kun Huang, Zhong Zou, Peilei Ren, Haiying Mao, Ying Yang, Shuo Gao, Xiaomei Sun, Xian Lin, Meilin Jin   +12 more
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Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses

Viruses, 2020
The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
José L. Martínez, Carlos F. Arias
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Epitranscriptomic regulation of viral replication

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
RNA plays central roles in biology and novel functions and regulation mechanisms are constantly emerging. To accomplish some of their functions within the cell, RNA molecules undergo hundreds of chemical modifications from which N6-methyladenosine (m6A), inosine (I), pseudouridine (ψ) and 5-methylcytosine (5mC) have been described in eukaryotic mRNA ...
Pereira-Montecinos, Camila, Valiente-Echeverría, Fernando, Soto Rifo, Ricardo   +2 more
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Annexin A1 Negatively Regulates Viral RNA Replication of Hepatitis C Virus

Annexin A1 Negatively Regulates Viral RNA Replication of Hepatitis C Virus, 2016
Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies.
Hiramoto, Hiroki, Dansako, Hiromichi, Takeda, Midori, Satoh, Shinya, Wakita, Takaji, Ikeda, Masanori, Kato, Nobuyuki   +6 more
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Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication

Viruses, 2014
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
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Vesicular stomatitis virus in Drosophila melanogaster cells: regulation of viral transcription and replication [PDF]

Journal of Virology, 1988
Vesicular stomatitis virus RNA synthesis was investigated during the establishment of persistent infection in Drosophila melanogaster cells. The transcription rate declined as early as 5 h after infection and was strongly inhibited after 7 h, leading to a decrease in viral mRNA levels and in viral protein synthesis rates.
D, Blondel, A M, Petitjean, S, Dezélée, F, Wyers   +3 more
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Molecular components of the circadian clock regulate HIV-1 replication

iScience, 2023
Summary: Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism’s response to its environment and ...
Helene Borrmann, Görkem Ulkar, Anna E. Kliszczak, Dini Ismed, Mirjam Schilling, Andrea Magri, James M. Harris, Peter Balfe, Sridhar Vasudevan, Persephone Borrow, Xiaodong Zhuang, Jane A. McKeating   +11 more
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Viral precursor polyproteins: keys of regulation from replication to maturation

Current Opinion in Virology, 2013
Many viruses use a replication strategy involving the translation of a large polyprotein, which is cleaved by viral and/or cellular proteases. Several of these viruses severely impact human health around the globe, including HIV, HCV, Dengue virus, and West Nile virus.
Yost, Samantha A, Marcotrigiano, Joseph
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Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication

Molecular Systems Biology, 2010
The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded
Christopher M Owens, Christina Mawhinney, Jill M Grenier, Ralf Altmeyer, Margaret S Lee, Alexis A Borisy, Joseph Lehár, Lisa M Johansen   +7 more
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