Results 1 to 10 of about 183,339 (262)

Epigenetic and epitranscriptomic regulation of viral replication. [PDF]

Nat Rev Microbiol, 2020
Eukaryotic gene expression is regulated not only by genomic enhancers and promoters, but also by covalent modifications added to both chromatin and RNAs. Whereas cellular gene expression may be either enhanced or inhibited by specific epigenetic modifications deposited on histones (in particular, histone H3), these epigenetic modifications can also ...
Tsai K, Cullen BR.
europepmc   +6 more sources

Regulation of viral replication by host restriction factors [PDF]

Frontiers in Immunology
Viral infectious diseases, caused by numerous viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A virus (IAV), enterovirus (EV), human immunodeficiency virus (HIV), hepatitis B virus (HBV), and human papillomavirus
Ying Lin, Ying Lin, Ying Lin, Yun Zhu, Yun Zhu, Ling Jing, Ling Jing, Ling Jing, Xiaobo Lei, Xiaobo Lei, Zhengde Xie, Zhengde Xie   +11 more
doaj   +4 more sources

Host cytoskeleton and membrane network remodeling in the regulation of viral replication. [PDF]

Biophys Rep
Viral epidemics pose major threats to global health and economies. A hallmark of viral infection is the reshaping of host cell membranes and cytoskeletons to form organelle-like structures, known as viral factories, which support viral genome replication. Viral infection in many cases induces the cytoskeletal network to form cage-like structures around
Gao X, Chen X, Yu L, Zhao S, Jiu Y.
europepmc   +3 more sources

SUMOylation in Viral Replication and Antiviral Defense

Advanced Science, 2022
SUMOylation is a ubiquitination‐like post‐translational modification that plays an essential role in the regulation of protein function. Recent studies have shown that proteins from both RNA and DNA virus families can be modified by SUMO conjugation ...
Yao Fan, Xiang Li, Lei Zhang, Zhi Zong, Fangwei Wang, Jun Huang, Linghui Zeng, Chong Zhang, Haiyan Yan, Long Zhang, Fangfang Zhou   +10 more
doaj   +1 more source

Defining the minimal components of the influenza A virus replication machinery via an in vitro reconstitution system.

PLoS Biology, 2023
During influenza A virus infection, the viral RNA polymerase transcribes the viral negative-sense segmented RNA genome and replicates it in a two-step process via complementary RNA within viral ribonucleoprotein (vRNP) complexes. While numerous viral and
Zihan Zhu, Haitian Fan, Ervin Fodor
doaj   +1 more source

Psoralen inhibits hepatitis B viral replication by down-regulating the host transcriptional machinery of viral promoters

Virologica Sinica, 2022
The hepatitis B virus (HBV) is a global public health challenge due to its highly contagious nature. It is estimated that almost 300 million people live with chronic HBV infection annually. Although nucleoside analogs markedly reduce the risk of liver disease progression, the analogs do not fully eradicate the virus.
Xinna Ma, Heng Li, Ying Gong, Feifei Liu, Xiankun Tong, Fenghua Zhu, Xiaoqian Yang, Li Yang, Jianping Zuo   +8 more
openaire   +2 more sources

Ubiquitination is required for effective replication of coxsackievirus B3. [PDF]

PLoS ONE, 2008
BACKGROUND: Protein ubiquitination and/or degradation by the ubiquitin/proteasome system (UPS) have been recognized as critical mechanisms in the regulation of numerous essential cellular functions.
Xiaoning Si, Guang Gao, Jerry Wong, Yahong Wang, Jingchun Zhang, Honglin Luo   +5 more
doaj   +1 more source

Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis. [PDF]

PLoS ONE, 2011
Adenoviruses (Ads), especially HAdV-5, have been genetically equipped with tumor-restricted replication potential to enable applications in oncolytic cancer therapy.
Dominik E Dorer, Frank Holtrup, Kurt Fellenberg, Johanna K Kaufmann, Sarah Engelhardt, Jörg D Hoheisel, Dirk M Nettelbeck   +6 more
doaj   +1 more source

Pre- and Post-Transcriptional Control of HBV Gene Expression: The Road Traveled towards the New Paradigm of HBx, Its Isoforms, and Their Diverse Functions

Biomedicines, 2023
Hepatitis B virus (HBV) is an enveloped DNA human virus belonging to the Hepadnaviridae family. Perhaps its main distinguishable characteristic is the replication of its genome through a reverse transcription process. The HBV circular genome encodes only
Rodrigo A. Villanueva, Alejandra Loyola
doaj   +1 more source

Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication

Frontiers in Veterinary Science, 2021
Peste des petits ruminant virus (PPRV) causes a highly contagious disease in small ruminants. The molecular mechanism of PPRV replication and its interactions with hosts are poorly studied.
Niyokwishimira Alfred, Niyokwishimira Alfred, Bang Qian, Xiaodong Qin, Xiangping Yin, Meera Prajapati, Meera Prajapati, Yongxi Dou, Yanmin Li, Zhidong Zhang   +9 more
doaj   +1 more source