Results 111 to 120 of about 3,451,628 (312)

Advice on standards for school premises: for local authorities, proprietors, school leaders, school staff and governing bodies [PDF]

, 2013
There are fewer regulations than previously and they are less prescriptive, allowing schools more flexibility in how they use their premises. - Many regulations state that provision must be ‘suitable’.

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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Phytochemical Profiling and Antimicrobial Properties of Various Sweet Potato (Ipomoea batatas L.) Leaves Assessed by RP-HPLC-DAD

Foods
This study aimed to investigate the leaves of six cultivars of Ipomoea batatas L. from the USA, focusing on their Total Polyphenol Content (TPC), Total Flavonoid Content (TFC), antioxidant, and antimicrobial activities.
Tasbida Sultana, Shahidul Islam, Muhammad Abul Kalam Azad, Md Jahurul Haque Akanda, Atikur Rahman, Md Sahidur Rahman   +5 more
doaj   +1 more source

Primer on Post Claims Underwriting and Rescission Practices: Findings From Texas in the Individual Health Insurance Market [PDF]

, 2009
Explains the practice of insurers canceling, rescinding, or limiting coverage after claims are submitted and the variations in regulations and enforcement.
Hilary Haycock, Peter Harbage
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In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Barriers to neurosurgical care in Gaza: navigating health system disruptions and scarcity of resources

Egyptian Journal of Neurosurgery
The ongoing conflict in Gaza has severely impacted the healthcare system, particularly in neurosurgery. Patients face significant challenges in accessing timely medical care due to movement restrictions, destruction of infrastructure, and a lack of ...
Muhammad Aashir Aftab, Eesha Yaqoob, Saad Javed, Bipin Chaurasia   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Analysis of the Application of Universal Design Standards to Interior-Architecture Design [PDF]

, 2019
A lot of research shows the findings of cases of public facilities that are not accessible to people with disabilities and see the importance of a design especially in the field of architecture-interior that is able to produce a user-friendly and barrier-
Cardiah, T. (Tita ), Firmansyah, R. (Rangga ), Hasanah, N. (Nisaul ), Syahida, A. N. (Arifah ), Wulandari, R. (Ratri )   +4 more
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Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Animal welfare in a global perspective [PDF]

, 2009
Global survey of animal-welfare regulations, practices and perceptions, with case studies on poultry meat from Brazil and Thailand, eggs from India and the USA, welfare regulations of farmed fish and welfare aspects related to (perceived) overpopulation ...
Bracke, M.B.M.
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