Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
A Man as the Regulator in Man-Machine Systems
Advances in Electrical and Electronic Engineering, 2014 The aim of the paper is to present the role of the human element in regularly used man-machine systems (MMS). From the technical point of view, it is possible to denote the human being and the machine as two components of one system.
Marie Havlikova +3 more
doaj +1 more source
The cingulate gyrus: Additional motor area and cortical autonomic regulator [PDF]
, 1959 Mary Jane C. Showers
openalex +1 more source
Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source
The Effect of the Plant Growth Regulator, 4-Chloro 2-Methy1 Phenoxyacetic Acid, on the Mineral and Nitrogen Contents of Plants [PDF]
, 1950 Anthony P. Rhodes +2 more
openalex +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
FURTHER EVIDENCE FOR A CHEMICAL REACTION BETWEEN PLANT GROWTH-REGULATORS AND A PLANT SUBSTRATE [PDF]
, 1951 Corwin Hansch +2 more
openalex +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Practical improvements to class group and regulator computation of real quadratic fields [PDF]
, 2010 We present improvements to the index-calculus algorithm for the computation of the ideal class group and regulator of a real quadratic field. Our improvements consist of applying the double large prime strategy, an improved structured Gaussian ...
Biasse, Jean-François +1 more
core +3 more sources