Results 71 to 80 of about 1,924,997 (302)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The restructuring and privatisation of British Rail: Was it really that bad? [PDF]

, 2002
This paper uses a social cost-benefit analysis (SCBA) framework to assess whether rail privatisation in Britain has produced savings in operating costs.
Beeching, Beeching, Bishop, Bradshaw, Burns, Chisari, Department of Transport, Domah, Estache, Europe Economics, Freeman, Galal, Gourvish, Health and Safety Commission, Jones, Kain, Martin, Monopolies and Mergers Commission, Monopolies and Mergers Commission, Monopolies and Mergers Commission, National Audit Office, National Audit Office, National Audit Office, National Audit Office, Newbery, Office of the Rail Regulator, Office of the Rail Regulator, Office of the Rail Regulator, Oum, Pollitt, SBC Warburg, Skamris, Yarrow   +32 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Increasing efficiency of switching type regulator circuits Patent [PDF]

, 1968
Switching series regulator with gating control ...
Clapp, W. M.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mepiquat chloride-driven regulation in cotton in China: a review of physiological mechanisms, agronomic integration, and future trajectories

Journal of Cotton Research
Crop chemical regulation using plant growth regulators (PGRs) represents a key strategy for achieving high-efficiency cotton production in China. This review synthesizes four decades of research on mepiquat chloride (MC), an inhibitory PGR pivotal to ...
Xinyao Liu, Yao Wang, Mingwei Du, Fangjun Li, Xiaoli Tian, Zhaohu Li   +5 more
doaj   +1 more source

MODIFIKASI DAN APLIKASI POWER WINDOW PADA TOYOTA HIACE [PDF]

, 2011
Tujuan Proyek Akhir ini adalah: (1) Dapat merancang power window tipe silang pada Toyota Hiace. (2) Dapat memodifikasi dan aplikasi power window tipe silang pada Toyota Hiace (3) Untuk mengetahui kinerja power window apakah dapat bekerja dengan baik ...
ASEP, TRIANTO
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

IMB2026791, a Xanthone, Stimulates Cholesterol Efflux by Increasing the Binding of Apolipoprotein A-I to ATP-Binding Cassette Transporter A1

Molecules, 2012
It is known that the ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and high density lipoprotein (HDL) metabolism. Several laboratories have demonstrated that ABCA1 binding to lipid-poor apolipoprotein A-I (apoA-
Zijian Xie, Bin Hong, Zhuorong Li, Wei Jiang, Tingting Feng, Yanni Xu, Zhongbing Zhang, Jikai Liu, Shuyi Si   +8 more
doaj   +1 more source

Underwater space suit pressure control regulator [PDF]

, 1973
A device is reported for regulating the pneumatic pressure in a ventilated space suit relative to the pressure imposed on the suit when being worn by a person underwater to simulate space environment for testing and experimentation. A box unit located on
Aldrich, B. R., Cooper, C. R., Rasquin, J. R.   +2 more
core   +1 more source