Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone +2 more
core +1 more source
Regulatory non-coding RNA: new instruments in the orchestration of cell death
Cell Death & Disease, 2016 AbstractNon-coding RNA (ncRNA) comprises a substantial portion of primary transcripts that are generated by genomic transcription, but are not translated into protein. The possible functions of these once considered ‘junk’ molecules have incited considerable interest and new insights have emerged.
Su, Ye +6 more
openaire +2 more sources
Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]
, 2015 The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Francesca Cordeiro, M +5 more
core +1 more source
Targeting cell death pathways in intestinal ischemia-reperfusion injury: a comprehensive review
Cell Death DiscoveryIntestinal ischemia-reperfusion (I/R) is a multifaceted pathological process, and there is a lack of clear treatment for intestinal I/R injury. During intestinal I/R, oxidative stress and inflammation triggered by cells can trigger a variety of cell ...
Fei Wang +5 more
doaj +1 more source
Affects of the inhibition of microRNA regulatory machinery in lymphoma cells [abstract] [PDF]
, 2010 MicroRNAs influence many processes such as development, cell proliferation and differentiation and cell death. MicroRNAs are intergrated into a complex called RISC with Argonatue proteins to target mRNAs.
Han, Autumn
core
LncRNA-driven programmed cell death networks: new therapeutic targets for neurological disorders
Frontiers in Molecular NeuroscienceNeural cell death is a critical pathological mechanism underlying the development and progression of central nervous system (CNS) diseases, where programmed cell death (PCD) pathways serve as critical regulatory hubs.
Zihong Xiong +4 more
doaj +1 more source
Effect of regulatory cell death on the occurrence and development of head and neck squamous cell carcinoma. [PDF]
Biomark Res, 2023 Xue Y +6 more
europepmc +1 more source
Critical Transitions In a Model of a Genetic Regulatory System
, 2014 We consider a model for substrate-depletion oscillations in genetic systems, based on a stochastic differential equation with a slowly evolving external signal. We show the existence of critical transitions in the system.
Berwald, Jesse, Gidea, Marian
core +1 more source
Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1
PLoS Biology, 2010 Immunotherapy using regulatory T cells (Treg) has been proposed, yet cellular and molecular mechanisms of human Tregs remain incompletely characterized. Here, we demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with reduced capacity to stimulate effector T cell responses.
Amarnath S +11 more
openaire +5 more sources
Mechanism of ferroptosis and its role in kidney diseases
Linchuang shenzangbing zazhi, 2021 Regulatory cell death（RCD） is essential for the development of organisms and the maintenance of homeostasis.Previously apoptosis was deemed as a sole form of RCD.However, recent studies have demonstrated that RCD could proceed through apoptosis or one of
Gong Mei-ling, Li Jun-hua
doaj