Results 171 to 180 of about 1,021,844 (200)

Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress–induced cell death

Blood, 2009
Abstract Although the authors of several studies report elevated numbers of immunosuppressive regulatory T cells (Tregs) in hematologic and solid malignancies, the underlying mechanism is not fully clarified. Cancer is associated with oxidative stress mediated through reactive oxygen species produced by malignant cells, granulocytes ...
Dimitrios, Mougiakakos, C Christian, Johansson, Rolf, Kiessling   +2 more
openaire   +2 more sources

Regulatory Strategies for Cell Death in Neurological Diseases

CNS & Neurological Disorders - Drug Targets, 2021
Yu-Hua, Chen, Kun, Xiong
openaire   +2 more sources

Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation

British Journal of Dermatology, 2015
Vitiligo is an autoimmune depigmentation disease, and defects in regulatory T cells (Tregs) have been proposed in the pathogenesis of generalized vitiligo (GV). However, the role of programmed cell death (PD)1(+) Tregs has not been studied.To investigate the status of Tregs, PD1(+) Tregs and associated parameters in active GV (aGV) during the first ...
M K, Tembhre, A S, Parihar, V K, Sharma, A, Sharma, P, Chattopadhyay, S, Gupta   +5 more
openaire   +2 more sources

Activation-Induced Programmed Cell Death of Nonspecific Cytotoxic Cells and Inhibition by Apoptosis Regulatory Factors

Cellular Immunology, 2000
Nonspecific cytotoxic cells (NCC) are the teleost equivalent of mammalian lymphokine-activated natural killer cells. The cytotoxic activities of NCC are enhanced by stress-activated serum factors (SASF) present in tilapia acute-phase serum. In the present study purified NCC and xenogeneic target HL-60 tumor cells and nuclei were distinguishable in ...
G R, Bishop, L, Jaso-Friedmann, D L, Evans   +2 more
openaire   +2 more sources

Management of ROS and Regulatory Cell Death in Myocardial Ischemia–Reperfusion Injury

Molecular Biotechnology
Myocardial ischemia-reperfusion injury (MIRI) is fatal to patients, leading to cardiomyocyte death and myocardial remodeling. Reactive oxygen species (ROS) and oxidative stress play important roles in MIRI. There is a complex crosstalk between ROS and regulatory cell deaths (RCD) in cardiomyocytes, such as apoptosis, pyroptosis, autophagy, and ...
Ge Gong, Wenhui Wan, Xinghu Zhang, Xiangxuan Chen, Jian Yin   +4 more
openaire   +2 more sources

The regulatory network and critical factors promoting programmed cell death during embryogenesis

Journal of Integrative Plant Biology
ABSTRACTProgrammed cell death (PCD) is essential for animal and plant development. However, the knowledge of the mechanism regulating PCD in plants remains limited, largely due to technical limitations. Previously, we determined that the protease NtCP14 could trigger PCD in the embryonic suspensor of tobacco (Nicotiana tabacum), providing a unique ...
An Luo, Ce Shi, Pan Luo, Zifu Zhao, Meng‐Xiang Sun   +4 more
openaire   +2 more sources

Decreased circulating CD39+ regulatory T cell frequencies following non-traumatic brain death

Transplant Immunology
Regulatory T cells (Tregs) are thought to modulate immune responses during Brain death (BD), However findings on their role remain controversial. This study aimed to assess the frequency of circulating Tregs in the peripheral blood of non-traumatic BD cases, specifically focusing on CD4+CD25+CD127low/-CD39+ Tregs and the levels of inflammatory cytokine
Sedighe Poursaleh, Amiri, Fattah Sotoudeh, Nejad, Maryam, Karamigolbaghi, Ehsan, Jafari, Behrouz, Robat-Jazi, Ahmadreza, Sadeghi, Seyed Ghasem Poursaleh, Amiri, Haideh, Namdari, Ali Akbar, Saboor-Yaraghi   +8 more
openaire   +2 more sources

Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death

Cancer Chemotherapy and Pharmacology, 2014
Glutathione S-transferases (GSTs) family of enzymes is best known for their cytoprotective role and their involvement in the development of anticancer drug resistance. Recently, emergence of non-detoxifying properties of GSTs has provided them with significant biological importance.
openaire   +2 more sources

A guide to cell death pathways

Nature Reviews Molecular Cell Biology, 2023
Junying Yuan, Dimitry Ofengeim
exaly  

Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death

Nature Reviews Molecular Cell Biology, 2023
Jarama Clucas, Pascal Meier
exaly