Results 11 to 20 of about 1,021,844 (200)
iPCD: A Comprehensive Data Resource of Regulatory Proteins in Programmed Cell Death
Cells, 2022 Programmed cell death (PCD) is an essential biological process involved in many human pathologies. According to the continuous discovery of new PCD forms, a large number of proteins have been found to regulate PCD.
Dachao Tang +7 more
doaj +3 more sources
Ferroptosis: new insight into the mechanisms of diabetic nephropathy and retinopathy
Frontiers in Endocrinology, 2023 Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the most serious and common diabetes-associated complications. DN and DR are all highly prevalent and dangerous global diseases, but the underlying mechanism remains to be elucidated ...
Luxin Li +15 more
doaj +1 more source
RIPK1 and RIPK3 inhibitors: potential weapons against inflammation to treat diabetic complications
Frontiers in Immunology, 2023 Diabetes mellitus is a metabolic disease that is characterized by chronic hyperglycemia due to a variety of etiological factors. Long-term metabolic stress induces harmful inflammation leading to chronic complications, mainly diabetic ophthalmopathy ...
Dan Ke +13 more
doaj +1 more source
The Role of Ferroptosis in the Treatment and Drug Resistance of Hepatocellular Carcinoma
Frontiers in Cell and Developmental Biology, 2022 Cell death is a fundamental feature of multicellular organisms’ development and a key driver of degenerative diseases. Ferroptosis is a new regulatory cell death mediated by iron-dependent lipid peroxidation, which is different from apoptosis and ...
Siqi Zhao +9 more
doaj +1 more source
Frontiers in Immunology, 2023 Copper, a transition metal, serves as an essential co-factor in numerous enzymatic active sites and constitutes a vital trace element in the human body, participating in crucial life-sustaining activities such as energy metabolism, antioxidation ...
Lei Gao, Anqi Zhang
doaj +1 more source
Regulatory mechanisms of RIPK1 in cell death and inflammation
Seminars in Cell & Developmental Biology, 2021 Receptor Interacting Protein Kinase 1 (RIPK1) and RIPK3 are key adaptors that play critical roles in inflammatory and cell death signaling. Work in recent years have shown that their activities are tightly regulated by ubiquitination, phosphorylation and proteolysis.
Zhijun, Liu, Francis Ka-Ming, Chan
openaire +3 more sources
Mathematical Models of Death Signaling Networks
Entropy, 2022 This review provides an overview of the progress made by computational and systems biologists in characterizing different cell death regulatory mechanisms that constitute the cell death network.
Madhumita Srinivasan +2 more
doaj +1 more source
Ferroptosis: a new strategy for cardiovascular disease
Frontiers in Cardiovascular Medicine, 2023 Cardiovascular disease (CVD) is currently one of the prevalent causes of human death. Iron is one of the essential trace elements in the human body and a vital component of living tissues.
Yuyuan Wang, Junduo Wu
doaj +1 more source
Brain Sciences, 2022 The heat-sink effect and thermal damage of conventional thermal ablative technologies can be minimized by irreversible electroporation (IRE), which results in clear ablative boundaries and conservation of blood vessels, facilitating maximal safe surgical
Shuangquan Yu +10 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Objective: Increasing evidence has uncovered the roles of lncRNA-miRNA-mRNA regulatory networks in cardiovascular diseases. However, the crosstalk between ceRNA networks and development of heart failure (HF) remains unclear. This study was to investigate
Yu Zheng +8 more
doaj +1 more source