Ferroptosis: The Silver Lining of Cancer Therapy
Frontiers in Cell and Developmental Biology, 2021 Regulatory cell death has been a major focus area of cancer therapy research to improve conventional clinical cancer treatment (e.g. chemotherapy and radiotherapy).
Zhengming Tang +9 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2023 Diabetes is a common chronic metabolic disease, and its incidence continues to increase year after year. Diabetic patients mainly die from various complications, with the most common being diabetic cardiomyopathy.
Dan Ke +12 more
doaj +1 more source
Effector Caspase Dcp-1 and IAP Protein Bruce Regulate Starvation-Induced Autophagy during Drosophila Melanogaster Oogenesis [PDF]
, 2008 A complex relationship exists between autophagy and apoptosis, but the regulatory mechanisms underlying their interactions are largely unknown. We conducted a systematic study of Drosophila melanogaster cell death–related genes to determine their ...
Barbosa, Sharon González +4 more
core +4 more sources
Deletion of AIF1 but not of YCA1/MCA1 protects Saccharomyces cerevisiae and Candida albicans cells from caspofungin-induced programmed cell death [PDF]
, 2014 Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the
Austriaco, Nicanor +5 more
core +3 more sources
Activation-induced cell death of self-reactive regulatory T cells drives autoimmunity [PDF]
Proceedings of the National Academy of Sciences, 2019 SignificanceIn the present study, we provide evidence of a cellular mechanism of breach of tolerance in an in vivo model of spontaneous autoimmune thyroiditis (AIT). We observe that self-antigen (Ag) specific Tregcirculate in all lymphatic tissues except for the lymph nodes (LNs) draining the thyroid, which represents the site of inflammation.
Badami, Ester +2 more
openaire +2 more sources
The p53-MDM2 network: from oscillations to apoptosis [PDF]
, 2007 The p53 protein is well-known for its tumour suppressor function. The p53-MDM2 negative feedback loop constitutes the core module of a network of regulatory interactions activated under cellular stress.
Bose, Indrani, Ghosh, Bhaswar
core +2 more sources
Protein-Thiol Oxidation and Cell Death: Regulatory Role of Glutaredoxins [PDF]
Antioxidants & Redox Signaling, 2012 Glutaredoxin (Grx) is the primary enzyme responsible for catalysis of deglutathionylation of protein-mixed disulfides with glutathione (GSH) (protein-SSG). This reversible post-translational modification alters the activity and function of many proteins important in regulation of critical cellular processes.
Erin M G, Allen, John J, Mieyal
openaire +2 more sources
Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses [PDF]
, 2020 The signalling pathways initiated by members of the transforming growth factor-β (TGFβ) family of cytokines control many metazoan cellular processes, including proliferation and differentiation, epithelial-mesenchymal transition (EMT) and apoptosis. TGFβ
A Rojas-Fernandez +63 more
core +2 more sources
Quantitative assessment of cell fate decision between autophagy and apoptosis [PDF]
, 2017 Autophagy and apoptosis are cellular processes that regulate cell survival and death, the former by eliminating dysfunctional components in the cell, the latter by programmed cell death.
Bahar, Ivet +6 more
core +3 more sources
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death [PDF]
, 2017 BACKGROUND: Apigenin is a flavonoid widely distributed in plant kingdom that exerts cytotoxic effects against a variety of solid and haematological cancers.
Cirone, Mara +5 more
core +3 more sources