Results 41 to 50 of about 1,021,844 (200)
Death receptor 3 signaling enhances proliferation of human regulatory T cells [PDF]
FEBS Letters, 2017 Exploiting regulatory T cells (Tregs) to control aberrant immune reactions is a promising therapeutic approach, but is hampered by their relative paucity. In mice, activation of death receptor 3 (DR3), a member of the TNF‐receptor superfamily (TNFRSF), increases Treg frequency and efficiently controls exuberant immune activation.
Sebastian Bittner +2 more
openaire +2 more sources
Cell Death and Disease, 2022 Activation of TNFR1 by TNFα induces the formation of a membrane-associated, intracellular complex termed complex I. Complex I orchestrates a complex pattern of modifications on key regulators of TNF signaling that collectively determines the cell fate by
Guowei Wu +10 more
doaj +1 more source
Molecular Events Involved in Influenza A Virus-Induced Cell Death
Frontiers in Microbiology, 2022 Viral infection usually leads to cell death. Moderate cell death is a protective innate immune response. By contrast, excessive, uncontrolled cell death causes tissue destruction, cytokine storm, or even host death.
Rui Gui, Rui Gui, Quanjiao Chen
doaj +1 more source
Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell death [PDF]
, 2016 © 2016 Authors. The pseudokinase mixed lineage kinase domain-like (MLKL) is an essential effector of necroptotic cell death. Two distinct human MLKL isoforms have previously been reported, but their capacities to trigger cell death have not been compared
Arnež, KH +5 more
core +3 more sources
Cutting Edge: Regulatory T Cells Do Not Mediate Suppression via Programmed Cell Death Pathways [PDF]
The Journal of Immunology, 2011 Abstract Regulatory T cells (Tregs) play a critical role in the immune system to regulate peripheral tolerance and prevent autoimmunity. However, the relative importance of different mechanisms of Treg function remains obscure. In this article, we reveal a limited role for programmed cell death pathways in mediating Treg suppression of ...
Andrea L, Szymczak-Workman +3 more
openaire +2 more sources
Distinct Types of Regulated Cell Death in Melanoma
CellsResistance to cell death is one of the core hallmarks of cancer, with regulatory abnormalities particularly pronounced in the malignant progression and therapeutic resistance of melanoma.
Qi Wu +4 more
doaj +1 more source
Diversification of a protein kinase cascade: IME-2 is involved in nonself recognition and programmed cell death in Neurospora crassa. [PDF]
, 2012 Kinase cascades and the modification of proteins by phosphorylation are major mechanisms for cell signaling and communication, and evolution of these signaling pathways can contribute to new developmental or environmental response pathways.
Bueche, Joanna A +2 more
core +2 more sources
Cell death affecting the progression of gastric cancer
Cell Death Discovery, 2022 Gastric cancer is a gastrointestinal tumor with high morbidity and mortality rates. Several factors influence its progression, cell death being an important element.
Haoying Wang +5 more
doaj +1 more source
Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]
, 2019 Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John +2 more
core +1 more source
Computational modeling of acute myocardial infarction [PDF]
, 2016 This is an Accepted Manuscript of an article published by Taylor & Francis Group in Computer Methods in Biomechanics and Biomedical Engineering on October, 2016, available online at: http://www.tandfonline.com/10.1080/10255842.2015.1105965Myocardial ...
Kuhl, E., Sáez Viñas, Pablo
core +2 more sources