Results 61 to 70 of about 1,021,844 (200)

The PI3K regulatory subunits p55α and p50α regulate cell death in vivo [PDF]

Cell Death & Differentiation, 2014
The phosphatidylinositol 3-kinase (PI3K) regulatory subunits p55α and p50α are coordinately transcriptionally upregulated by signal transducer and activator of transcription 3 (Stat3) at the onset of mammary gland involution, a process that requires Stat3.
S Pensa, K Neoh, H K Resemann, P A Kreuzaler, K Abell, N J Clarke, T Reinheckel, C R Kahn, C J Watson   +8 more
openaire   +3 more sources

Arabidopsis cell suspension culture and RNA sequencing reveal regulatory networks underlying plant programmed cell death

The Plant Journal, 2023
AbstractProgrammed cell death (PCD) facilitates targeted elimination of redundant, damaged, or infected cells via genetically controlled pathways. In plants, PCD is often an essential component of normal development and can also mediate responses to abiotic and biotic stress stimuli.
Rory Burke, Aideen McCabe, Neetu Ramesh Sonawane, Meet Hasmukh Rathod, Conor Whelan, Paul F. McCabe, Joanna Kacprzyk   +6 more
openaire   +2 more sources

Dynamics of gene expression and the regulatory inference problem

, 2008
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times.
, Alon U., Chen W. England J. Shakhnovich E., Hertz J., Honerkamp J., J. Berg, Lèbre S., Michaelis L., Spellman P. T., Stokic D. Hanel R. Thurner S., van Kampen N.   +10 more
core   +1 more source

Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]

, 2015
BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu, Deng, Wenbin, Liu, Wenwei, Xiao, Juan   +3 more
core   +2 more sources

Therapeutic effects of natural compounds against diabetic complications via targeted modulation of ferroptosis

Frontiers in Pharmacology
Diabetes mellitus, a chronic metabolic disorder, can result in serious tissue and organ damage due to long-term metabolic dysfunction, leading to various complications.
Zhen Zhang, Zhen Zhang, Luxin Li, Wei Fu, Zhengchao Fu, Mahang Si, Siyu Wu, Yueying Shou, Xinyu Pei, Xiaoyi Yan, Chenguang Zhang, Tong Wang, Fei Liu   +12 more
doaj   +1 more source

The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity [PDF]

, 2016
Plant NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), produce reactive oxygen species (ROS) that perform a wide range of functions.
Antonio Molina, Berrocal-Lobo, Cyril Zipfel, Jefferson, Jorge Morales, Miguel-Angel Torres, Yasuhiro Kadota   +6 more
core   +1 more source

Chlormequat Chloride Inhibits TM3 Leydig Cell Growth via Ferroptosis-Initiated Inflammation

Cells
Ferroptosis hallmarked by lipid peroxidation and iron homeostasis imbalance is involved in the occurrence and development of various diseases. The plant growth regulator chlormequat chloride (CCC) can contribute to the causality and exacerbation of ...
Xiaoxia Wang, Chenping Kang, Wanqian Guo, Haoran Zhang, Qianqian Xiao, Weidong Hao   +5 more
doaj   +1 more source

Ions, the Movement of Water and the Apoptotic Volume Decrease

Frontiers in Cell and Developmental Biology, 2020
The movement of water across the cell membrane is a natural biological process that occurs during growth, cell division, and cell death. Many cells are known to regulate changes in their cell volume through inherent compensatory regulatory mechanisms ...
Carl D. Bortner, John A. Cidlowski
doaj   +1 more source

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication [PDF]

, 2017
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression.
Beckerman, Bronte, Catherine A. Vaughan, Frum, Lin, Luzhna, Olivier, Oren, Rebecca A. Frum, Shilpa Singh, Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Zeman, Zuazua-Villar   +14 more
core   +2 more sources

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources