Results 81 to 90 of about 1,021,844 (200)

Pyroptosis, ferroptosis, and autophagy in spinal cord injury: regulatory mechanisms and therapeutic targets

Neural Regeneration Research
Regulated cell death is a form of cell death that is actively controlled by biomolecules. Several studies have shown that regulated cell death plays a key role after spinal cord injury.
Qingcong Zheng, Du Wang, Rongjie Lin, Weihong Xu   +3 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL. [PDF]

, 2019
The risk for non-Hodgkin lymphoma (NHL) is markedly increased in persons living with human immunodeficiency virus (HIV) infection, and remains elevated in those on anti-retroviral therapy (cART).
Conti, David V, Cozen, Wendy, Epeldegui, Marta, Guo, Yu, Martínez-Maza, Otoniel, Penichet, Manuel L   +5 more
core  

Bypassing drug resistance by triggering necroptosis: recent advances in mechanisms and its therapeutic exploitation in leukemia

Journal of Experimental & Clinical Cancer Research, 2018
Resistance to regulated cell death is one of the hallmarks of human cancers; it maintains cell survival and significantly limits the effectiveness of conventional drug therapy. Leukemia represents a class of hematologic malignancies that is characterized
Xianbo Huang, Feng Xiao, Yuan Li, Wenbin Qian, Wei Ding, Xiujin Ye   +5 more
doaj   +1 more source

Anti-programmed cell death protein-1/ligand-1 therapy in different cancers. [PDF]

, 2015
Immunologic checkpoint blockade with antibodies against the programmed cell death protein-1 (PD-1) or its ligand (PD-L1) is an effective method for reversing cancer immunosuppression and thereby promoting immune responses against several cancer types ...
Homet Moreno, B, Ribas, A
core   +2 more sources

Non-coding RNAs are involved in tumor cell death and affect tumorigenesis, progression, and treatment: a systematic review

Frontiers in Cell and Developmental Biology
Cell death is ubiquitous during development and throughout life and is a genetically determined active and ordered process that plays a crucial role in regulating homeostasis.
Zeping Han, Zeping Han, Wenfeng Luo, Jian Shen, Fangmei Xie, Jinggen Luo, Xiang Yang, Ting Pang, Yubing Lv, Yuguang Li, Xingkui Tang, Jinhua He, Jinhua He   +12 more
doaj   +1 more source

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M., Bettelli, Estelle, Buch, Thorsten, Frommer, Friederike, Heinen, Tobias J. A. J., Mueller, Werner, Roers, Axel, Waisman, Ari, Wunderlich, F. Thomas, Yogev, Nir   +9 more
core   +1 more source

Exosomes derived from programmed cell death: mechanism and biological significance

Cell Communication and Signaling
Exosomes are nanoscale extracellular vesicles present in bodily fluids that mediate intercellular communication by transferring bioactive molecules, thereby regulating a range of physiological and pathological processes.
Min Xiong, Zhen Chen, Jiaqi Tian, Yanjie Peng, Dandan Song, Lin Zhang, Yulan Jin   +6 more
doaj   +1 more source

PANoptosis nexus in ischemia-reperfusion injury: from integrated cell death mechanisms to novel therapeutic opportunities

Frontiers in Immunology
Ischemia-reperfusion injury (IRI) can activate multiple cell death pathways, leading to dysfunction of multiple organs. PANoptosis is a new inflammatory cell death form recently discovered and it is also an integrated cell death mode, which includes the ...
Hongyang Chen, Hongyang Chen, Hongyang Chen, Jingsheng Men, Tianyou Gao, Fengli Ma, Zhuangzhuang Jia, Zhuangzhuang Jia, Zhuangzhuang Jia   +8 more
doaj   +1 more source

Identification of control targets in Boolean molecular network models via computational algebra [PDF]

, 2016
Motivation: Many problems in biomedicine and other areas of the life sciences can be characterized as control problems, with the goal of finding strategies to change a disease or otherwise undesirable state of a biological system into another, more ...
Aguilar, Boris, Laubenbacher, Reinhard, Murrugarra, David, Veliz-Cuba, Alan   +3 more
core   +5 more sources