Results 111 to 120 of about 5,141,166 (402)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Disease heritability enrichment of regulatory elements is concentrated in elements with ancient sequence age and conserved function across species

bioRxiv, 2018
Regulatory elements, e.g. enhancers and promoters, have been widely reported to be enriched for disease and complex trait heritability. We investigated how this enrichment varies with the age of the underlying genome sequence, the conservation of ...
Margaux L. A. Hujoel, S. Gazal, F. Hormozdiari, Bryce van de Geijn, A. Price   +4 more
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Highly Specific Epigenome Editing by CRISPR/Cas9 Repressors for Silencing of Distal Regulatory Elements

Nature Methods, 2015
Epigenome editing with the CRISPR (clustered, regularly interspaced, short palindromic repeats)-Cas9 platform is a promising technology for modulating gene expression to direct cell phenotype and to dissect the causal epigenetic mechanisms of gene ...
P. Thakore, A. D'Ippolito, Lingyun Song, Alexias Safi, Nishkala Shivakumar, Ami M. Kabadi, Timothy E. Reddy, G. Crawford, C. Gersbach   +8 more
semanticscholar   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Systematic identification and characterization of regulatory elements derived from human endogenous retroviruses

PLoS Genetics, 2017
Human endogenous retroviruses (HERVs) and other long terminal repeat (LTR)-type retrotransposons (HERV/LTRs) have regulatory elements that possibly influence the transcription of host genes. We systematically identified and characterized these regulatory
Jumpei Ito, Ryota Sugimoto, H. Nakaoka, S. Yamada, Tetsuaki Kimura, Takahide Hayano, I. Inoue   +6 more
semanticscholar   +1 more source

Regression trees for regulatory element identification [PDF]

Bioinformatics, 2004
Abstract Motivation: The transcription of a gene is largely determined by short sequence motifs that serve as binding sites for transcription factors. Recent findings suggest direct relationships between the motifs and gene expression levels. In this work, we present a method for identifying regulatory motifs.
Phuong T.M., Lee D. Lee, Doheon, Lee K.H. Lee, Kwang-Hyung   +2 more
openaire   +4 more sources

Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex. [PDF]

, 2014
BackgroundThe genetic programs required for development of the cerebral cortex are under intense investigation. However, non-coding DNA elements that control the expression of developmentally important genes remain poorly defined. Here we investigate the
Chen, Bin, Eckler, Matthew J, Guo, Chao, Katzman, Sol, Larkin, Kathryn A, McKenna, William L, Roque, Robin, Rubenstein, John LR, Visel, Axel   +8 more
core   +4 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The interdependence of gene-regulatory elements and the 3D genome

Journal of Cell Biology, 2018
&NA; Imaging studies, high‐resolution chromatin conformation maps, and genome‐wide occupancy data of architectural proteins have revealed that genome topology is tightly intertwined with gene expression.
M. Vermunt, Di Zhang, G. Blobel
semanticscholar   +1 more source