Results 121 to 130 of about 5,375,401 (399)

Statistically Significant Strings are Related to Regulatory Elements in the Promoter Regions of Saccharomyces cerevisiae [PDF]

, 2000
Finding out statistically significant words in DNA and protein sequences forms the basis for many genetic studies. By applying the maximal entropy principle, we give one systematic way to study the nonrandom occurrence of words in DNA or protein ...
Bin Wang, Burge, Derisi, Goffeau, Helden, Hertz, Hinnebusch, Honerkamp, Lawrence, Li, Mantegna, Peng, Pevzer, Phillips, Rui Hu, Shannon, Zhang, Zhu   +17 more
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche

Cell Reports, 2016
In vertebrate embryos, anterior tissues are generated early, followed by the other axial structures that emerge sequentially from a posterior growth zone. The genetic network driving posterior axial elongation in mice, and its disturbance in mutants with
Shilu Amin, Roel Neijts, Salvatore Simmini, Carina van Rooijen, Sander C. Tan, Lennart Kester, Alexander van Oudenaarden, Menno P. Creyghton, Jacqueline Deschamps   +8 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Information system of regulatory elements. [PDF]

, 2011
The study of the transcriptome of a particular plant species, associated with these stresses, is a powerful tool in the new sequencing technologies that enable mass scanning of the genome at a speed, accuracy and unprecedented scale generating a huge ...
BEVITORI, R., NARCISO, M. G.
core  

Genetic determinants of co-accessible chromatin regions in activated T cells across humans. [PDF]

, 2018
Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease.
A Barrie, A Battle, A Franke, AA Shabalin, AM Klein, AR Quinlan, Atsede Siba, Aviv Regev, Aviva P. Aiden, B Li, BE Stranger, C Hou, Christine S. Cheng, Christophe Benoist, Chun J. Ye, CJ Ye, CK Stroud, D Hnisz, D Lee, D Sakata, DE Speiser, Dmytro Lituiev, E Elinav, E Splinter, EM Schmidt, Erez Lieberman Aiden, EZ Macosko, G Jun, G McVicker, H Kilpinen, H Li, H Li, HK Finucane, HM Kang, Howard Y. Chang, Ido Machol, Ivo Wortman, J Yang, JD Buenrostro, JD Buenrostro, JD Storey, JE Phillips, JF Degner, JN Hirschhorn, JS Delisle, K Enjyoji, Kendrick L. Hougen, KK Farh, L Chen, L Plesner, M Feuerer, M Ghandi, M Kasowski, M Kronenberg, M Kurachi, M. Grace Gordon, Marcin Tabaka, MB Gerstein, Meena Subramaniam, MI Love, MI McCarthy, Michael A. Beer, MN Lee, MT Maurano, Muhammad Shamim, MY Donath, N Kumasaka, NC Durand, Neva C. Durand, NP Restifo, P Cauchy, P Li, PC Hollenhorst, Philip L. De Jager, PM Visscher, PS Ohashi, R Satija, Rachel E. Gate, RE Thurman, RM Samstein, Roadmap Epigenomics Consortium,, S Deaglio, S Heinz, S Neph, SM Waszak, SS Rao, Su-Chen Huang, T Lappalainen, T Raj, The ENCODE Project Consortium., Ting Feng, TL Murphy, UM Marigorta, WA Whyte, WJ Astle, X Chen, X Sun, Y Belkaid, Y Zhang, YY Fan   +99 more
core   +2 more sources

Primary transcriptome and translatome analysis determines transcriptional and translational regulatory elements encoded in the Streptomyces clavuligerus genome

Nucleic Acids Research, 2019
Determining transcriptional and translational regulatory elements in GC-rich Streptomyces genomes is essential to elucidating the complex regulatory networks that govern secondary metabolite biosynthetic gene cluster (BGC) expression.
Soonkyu Hwang, Namil Lee, Yujin Jeong, Yongjae Lee, Woori Kim, Suhyung Cho, B. Palsson, Byung-Kwan Cho   +7 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Identification of functional cis-regulatory elements by sequential enrichment from a randomized synthetic DNA library [PDF]

, 2013
BACKGROUND: The identification of endogenous cis-regulatory DNA elements (CREs) responsive to endogenous and environmental cues is important for studying gene regulation and for biotechnological applications but is labor and time intensive. Alternatively,
Ahmadinejad, N., Colby, T., Roccaro, M., Somssich, I.   +3 more
core   +2 more sources

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Nature Biotechnology, 2017
Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes.
Tyler S. Klann, Joshua B. Black, M. Chellappan, Alexias Safi, Lingyun Song, Isaac B. Hilton, G. Crawford, Timothy E. Reddy, C. Gersbach   +8 more
semanticscholar   +1 more source