Results 131 to 140 of about 5,141,166 (402)
Identification of regulatory elements from nascent transcription using dREG
bioRxiv, 2018 Our genomes encode a wealth of transcription initiation regions (TIRs) that can be identified by their distinctive patterns of actively elongating RNA polymerase. We previously introduced dREG to identify TIRs using PRO-seq data.
Zhong Wang +3 more
semanticscholar +1 more source
Transposable Elements, Inflammation, and Neurological Disease. [PDF]
, 2019 Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela +2 more
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cis-regulatory circuits regulating NEK6 kinase overexpression in transformed B cells Are super-enhancer independent [PDF]
, 2017 Alterations in distal regulatory elements that control gene expression underlie many diseases, including cancer. Epigenomic analyses of normal and diseased cells have produced correlative predictions for connections between dysregulated enhancers and ...
Huang, Yue +6 more
core +3 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Engineering Complexity in Bacterial Regulatory Circuits for Biotechnological Applications
mSystems, 2018 Engineering microbial systems allows the generation of new technologies having significant impact in the biotechnological industry and on human health. In the past few years, several synthetic biology approaches have been implemented in bacteria to allow
Cauã Antunes Westmann +2 more
doaj +1 more source
Metagenomic mining of regulatory elements enables programmable species-selective gene expression
Nature Methods, 2018 Robust and predictably performing synthetic circuits rely on the use of well-characterized regulatory parts across different genetic backgrounds and environmental contexts.
Nathan I. Johns +9 more
semanticscholar +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
Frontiers in Microbiology, 2019 The infections caused by Dickeya zeae become a severe problem in recent years, but the regulatory mechanisms that govern the bacterial virulence remain to be fragmental.
Zurong Shi +14 more
doaj +1 more source
Cis-regulatory elements used to control gene expression in plants
Plant Cell Tissue and Organ Culture, 2016 Plant biotechnology is a dynamically developing science, which comprises many fields of knowledge. Novel plant genetic engineering findings highly influence the improvement of industrial production.
Róża Biłas +3 more
semanticscholar +1 more source
Information system of regulatory elements. [PDF]
, 2011 The study of the transcriptome of a particular plant species, associated with these stresses, is a powerful tool in the new sequencing technologies that enable mass scanning of the genome at a speed, accuracy and unprecedented scale generating a huge ...
BEVITORI, R., NARCISO, M. G.
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