Results 281 to 290 of about 5,141,166 (402)

Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi. [PDF]

Sci Rep
Gonzalez E, Anderson MAE, Ang JXD, Nevard K, Shackleford L, Larrosa-Godall M, Leftwich PT, Alphey L.   +7 more
europepmc   +1 more source

Differentiation-dependent human immunodeficiency virus long terminal repeat regulatory elements active in human teratocarcinoma cells [PDF]

, 1992
Steven L. Zeichner, Gábor Hirka, Peter W. Andrews, James C. Alwine   +3 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Genome-wide identification of the H3K27ac signals reveals key thermogenic cis-regulatory elements of brown adipose tissues in Oryctolagus cuniculus. [PDF]

BMC Genomics
Du K, Wu Q, Gan YX, Tang XY, Zan JX, Sun WQ, Luo G, Chen XW, Wang DH.   +8 more
europepmc   +1 more source

Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system

, 1991
Hiromichi Suzuki, Yoshitaka Hosokawa, Morimitsu Nishikimi, Takayuki Ozawa   +3 more
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Mining of Root-Specific Expression Genes and Their Core Cis-Regulatory Elements in Plants. [PDF]

Int J Mol Sci
Gao S, Chai Y, Zhou X, Chen S.
europepmc   +1 more source

Multiple regulatory elements control expression of the gene encoding the Saccharomyces cerevisiae cytochrome P450, lanosterol 14 alpha-demethylase (ERG11).

, 1992
Thomas G. Turi, Joyce E. Loper
openalex   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Drug-induced cis-regulatory elements in human hepatocytes affect molecular phenotypes associated with adverse reactions. [PDF]

Nat Commun
Gotoh-Saito S, Wada R, Nishimura T, Kawaji H.   +3 more
europepmc   +1 more source