Results 281 to 290 of about 5,375,401 (399)

Fast and Accurate Clustering of Single Cell Epigenomes Reveals Cis-Regulatory Elements in Rare Cell Types

, 2019
Rongxin Fang, Sebastian Preissl, Y. Li, Xiaomeng Hou, J. Lucero, Xinxin Wang, Amir Motamedi, A. Shiau, Xinzhu Zhou, Fangming Xie, E. Mukamel, Kai Zhang, Yanxiao Zhang, M. Behrens, J. Ecker, B. Ren   +15 more
semanticscholar   +1 more source

De novo mutations in regulatory elements in neurodevelopmental disorders

Nature, 2018
Patrick J. Short, J. McRae, G. Gallone, A. Sifrim, H. Won, D. Geschwind, C. Wright, H. Firth, D. FitzPatrick, J. Barrett, M. Hurles   +10 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci. [PDF]

Cell Genom
Zhao K, Zhou Y, Wang X, Wang Z, Xu X, Chen Y, Zhao L, Wu C, Wang J, Yao H, Cheng X, Wang W, Chu X, Wang W, Yi X, Chen Y, Li M, Lu W, Chen K, Sham PC, Huang D, Zhang J, Li MJ.   +22 more
europepmc   +1 more source

Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements

Science, 2018
Bo Gu, T. Swigut, Andrew Spencley, Matthew R. Bauer, Mingyu Chung, T. Meyer, J. Wysocka   +6 more
semanticscholar   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Single-cell multi-omics analysis reveals cancer regulatory elements of transcriptional programs and clinical implications. [PDF]

Cell Death Dis
Tang X, Zhang Q, Shen Z, Xiao J, Li M, Meng X, Wang C, Zhang G, Liu A, Yin Y.   +9 more
europepmc   +1 more source

Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system

, 1991
Hiromichi Suzuki, Yoshitaka Hosokawa, Morimitsu Nishikimi, Takayuki Ozawa   +3 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recruitment of transcriptional effectors by Cas9 creates <i>cis</i>-regulatory elements and demonstrates distance-dependent transcriptional regulation. [PDF]

iScience
Boulos J, Golov AK, Keren N, Erlich I, Shehadeh N, Avidan N, Kariti H, Sadeh O, Haimovich-Caspi L, Helms A, Kaplan N, Kehat I.   +11 more
europepmc   +1 more source