Results 81 to 90 of about 5,141,166 (402)

Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq. [PDF]

, 2019
One of the primary aims of the Functional Annotation of ANimal Genomes (FAANG) initiative is to characterize tissue-specific regulation within animal genomes.
Bellone, Rebecca R, Creppe, Catherine, Finno, Carrie J, Hales, Erin N, Kalbfleisch, TS, Kern, Colin, Kingsley, NB, MacLeod, James N, Petersen, Jessica L, Zhou, Huaijun   +9 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation

Frontiers in Genome Editing, 2023
DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network.
Jeong Hoon Han, Hong Jo Lee, Tae Hyun Kim, Tae Hyun Kim   +3 more
doaj   +1 more source

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]

, 2010
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A, Bishop, Eric P, Canfield, Theresa K, Elgin, Sarah CR, Ernst, Jason, Gorchakov, Andrey A, Gu, Tingting, Jung, Youngsook L, Karpen, Gary H, Kellis, Manolis, Kharchenko, Peter V, Kuroda, Mitzi I, Larschan, Erica, Linder-Basso, Daniela, Luquette, Lovelace J, MacAlpine, David M, Minoda, Aki, Park, Peter J, Park, Richard W, Pirrotta, Vincenzo, Plachetka, Annette, Riddle, Nicole C, Sabo, Peter J, Sandstrom, Richard, Schwartz, Yuri B, Shanower, Gregory, Stamatoyannopoulos, John A, Thurman, Robert E, Tolstorukov, Michael Y, Xi, Ruibin   +29 more
core   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Presenting a Meta-Heuristic Algorithm to Detect Regulatory Elements in the Genome of Breast Cancer Patients [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Nowadays, in medical sciences, the amount of data on symptoms of people affected with various illnesses on one hand, and finding assistive techniques for the diagnosis of those diseases on the other, has been widespread ...
mohammadjavad hosseinpoor, hamid parvin, samad nejatian, Vahideh Rezaee, Karamollah bagherifard   +4 more
doaj  

Quality of regulatory elements in Drosophila retrogenes

Genomics, 2009
Retrogenes are processed copies of genes that are inserted into new genomic regions and that acquire new regulatory elements from the sequences in their surroundings. Here we use a comparative approach of phylogenetic footprinting and a non-comparative approach of measuring motif over-representation in retrogenes in order to describe putative elements ...
Esther Betrán, Claudio Casola, Claudio Casola, Yongsheng Bai   +3 more
openaire   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Sheep genome functional annotation reveals proximal regulatory elements contributed to the evolution of modern breeds

Nature Communications, 2018
Domestication fundamentally reshaped animal morphology, physiology and behaviour, offering the opportunity to investigate the molecular processes driving evolutionary change. Here we assess sheep domestication and artificial selection by comparing genome
M. Naval-Sánchez, Quan Nguyen, Sean McWilliam, L. Porto-Neto, R. Tellam, T. Vuocolo, A. Reverter, M. Pérez-Enciso, R. Brauning, S. Clarke, A. McCulloch, W. Zamani, S. Naderi, H. Rezaei, F. Pompanon, P. Taberlet, K. Worley, R. Gibbs, D. Muzny, S. Jhangiani, N. Cockett, H. Daetwyler, J. Kijas   +22 more
semanticscholar   +1 more source

Uncovering Drug-Responsive Regulatory Elements

Pharmacogenomics, 2015
Nucleotide changes in gene regulatory elements can have a major effect on interindividual differences in drug response. For example, by reviewing all published pharmacogenomic genome-wide association studies, we show here that 96.4% of the associated single nucleotide polymorphisms reside in noncoding regions. We discuss how sequencing technologies are
Luizon, Marcelo R, Ahituv, Nadav
openaire   +5 more sources