Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Risk and Reward: Regulatory Focus Orientation and the Effectiveness of Promotion and Prevention Targeted Organizational Apologies [PDF]
Management and Economics ReviewOrganisations are expected to apologise when they cause offense, but apologies sometimes fail to restore trust. This study applies regulatory focus theory (RFT) to examine why some apologies are more effective than others based on the inclusion of ...
Eric RHODES +2 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The three criteria test, the essential facilities doctrine and the theory of monopolistic bottlenecks [PDF]
The focus of this paper is on regulatory reforms towards rule-based regulation. The theory of monopolistic bottlenecks is contrasted with the concept of essential facilities and the so-called three-criteria test.
Knieps, Günter
core
Identifying dynamical modules from genetic regulatory systems: applications to the segment polarity network [PDF]
, 2007 BACKGROUND It is widely accepted that genetic regulatory systems are 'modular', in that the whole system is made up of smaller 'subsystems' corresponding to specific biological functions.
D Irons +15 more
core +5 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Contents of Hopes and Duties: A Linguistic Analysis
Frontiers in Psychology, 2018 People in a prevention focus tend to view their goals as duties and obligations, whereas people in a promotion focus tend to view their goals as hopes and aspirations.
Leigh Ann Vaughn
doaj +1 more source
ADVERTISING AND PRODUCT TRIAL - THE EFFECT OF MESSAGE’S REGULATORY FOCUS AND PRODUCT TYPE ON CONSUMER EVALUATIONS [PDF]
The objective of this research is to examine the effect of message’s regulatory focus (promotion versus prevention) and product types (hedonic versus utilitarian) on advertising effectiveness, as well as how direct product experience alters these effects.
Camelia C. MICU
core
Adaptive Financial Regulation and RegTech: A Concept Article on Realistic Protection for Victims of Bank Failures [PDF]
, 2016 Frustrated by the seeming inability of regulators and prosecutors to hold bank executives to account for losses inflicted by their companies before, during, and since the financial crisis of 2008, some scholars have suggested that private-attorney ...
Baxter, Lawrence G.
core +2 more sources