Results 191 to 200 of about 29,276,589 (300)

Achieving Representation in Cardiovascular Device Clinical Research: The Role of Regulatory Science. [PDF]

J Soc Cardiovasc Angiogr Interv
Batchelor WB, Coylewright M, Jamil Y, White R, Spitzer E, Hanafi N, Jaff MR, Chapman R, Stephens D, Krucoff MW.   +9 more
europepmc   +1 more source

Recommendation of Regulatory Science Education in Pharmaceutical Science

YAKUGAKU ZASSHI, 2017
Shingo, Niimi, Makoto, Shiragami
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Editorial: Reviews in: regulatory science 2024-2025. [PDF]

Front Med (Lausanne)
Thomsen MDT, Knudsen LE.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non-Clinical Evidence, and Regulatory Science. [PDF]

J Clin Pharmacol
Wen YF, Wang X, Boyanapalli S, Anderson L, Dang T, Xing G, Calvet M, Hart T, Kasichayanula S, Zhao X.   +9 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Scaling medical device regulatory science using large language models. [PDF]

NPJ Digit Med
Li H, He X, Subbaswamy A, Vossler P, Gossmann A, Singh K, Feng J.   +6 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Regulatory science for AI-based <i>software as a medical device</i> in computational pathology and biomarker-driven drug development. [PDF]

J Pathol Inform
Liebes-Peer Y, Czeisler S, Broderick R, Vecsler M, Heller Y, Linhart C, Mossel J, Lennerz JK.   +7 more
europepmc   +1 more source