Results 201 to 210 of about 7,752,988 (327)

The tip of the iceberg: Profiling cooling agents using computational approaches to inform tobacco regulatory science. [PDF]

PLoS One
Chakraborty S, Venugopal PD, Kaltcheva M, Kang JC, Goel R.   +4 more
europepmc   +1 more source

Food Labels: Implications for U.S. Agricultural Imports [PDF]

Labels have been used to make food attributes transparent and to satisfy the increasing consumer demand for information about food credence values. Several types of prevalent U.S.
Henneberry, Shida Rastegari, Mutondo, Joao E.   +1 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Emulating the LEADER trial in China: a regulatory science case study on non-interventional research. [PDF]

Front Endocrinol (Lausanne)
Zhao J, Xin X, Song Y, Zhang J, Wu Y, Wang J, Cui F.   +6 more
europepmc   +1 more source

Application of implementation science framework to develop and adopt regulatory science in different national regulatory authorities. [PDF]

Front Public Health, 2023
Shi J, Chen X, Hu H, Ung COL.
europepmc   +1 more source

Why forums? An empirical analysis into the facilitating factors of carding forums

, 2013
Over the last decade, the nature of cybercrime has transformed from naive vandalism to profit-driven, leading to the emergence of a global underground economy. A noticeable trend which has surfaced in this economy is the repeated use of forums to operate
Shadbolt, Nigel, Webber, Craig, Yip, Michael   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Guidance for the Methodological Challenges of Polytobacco Use in Tobacco Regulatory Science. [PDF]

Public Health Rep
Mermelstein R, Pentz MA, Hedeker D, Audrain-McGovern J, Fleischer NL, Bray B, Giovenco DP, Mayne RG, Hirschtick JL, Mackinnon DP, Strong D, Price S, Stanton CA.   +12 more
europepmc   +1 more source

Toxicoepigenetics for Risk Assessment: Bridging the Gap Between Basic and Regulatory Science. [PDF]

Epigenet Insights, 2022
Le Goff A, Louvel S, Boullier H, Allard P.   +3 more
europepmc   +1 more source