Results 41 to 50 of about 29,276,589 (300)

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Risk assessment of homologous variants of biotech trait proteins using a bridging approach

GM Crops & Food
A transgenic protein is frequently expressed as different homologous variants in genetically modified crops due to differential processing of targeting peptides or optimization of activity and specificity.
Cunxi Wang, Jennifer Calcaterra, Beverly Anderson, Timothy Rydel, Rong Wang, Lieselot Bertho, Scott A. Saracco, Kimberly Hodge-Bell, Luis Burzio, Tommi White, Bin Li   +10 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Predicting potential adverse events using safety data from marketed drugs

BMC Bioinformatics, 2020
Background While clinical trials are considered the gold standard for detecting adverse events, often these trials are not sufficiently powered to detect difficult to observe adverse events.
Chathuri Daluwatte, Peter Schotland, David G. Strauss, Keith K. Burkhart, Rebecca Racz   +4 more
doaj   +1 more source

First-line sintilimab plus chemotherapy in locally advanced or metastatic esophageal squamous cell carcinoma: A cost-effectiveness analysis from China

Frontiers in Pharmacology, 2022
Objective: The study aimed to assess the cost-effectiveness of sintilimab combined with cisplatin plus paclitaxel versus chemotherapy alone as first-line treatment in patients with advanced or metastatic esophageal squamous cell carcinoma from the ...
Jian Shen, Jian Shen, Yi Du, Yi Du, Rong Shao, Rong Shao, Rong Jiang, Rong Jiang   +7 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Optimizing the implementation of safe and sustainable by design to better enable sustainable innovation

iScience
Summary: The concept of safe and sustainable by design (SSbD) combines considerations of human safety, environmental safety, and sustainability. The SSbD framework developed by the European Commission’s (EC) Joint Research Centre (JRC) and the Safe(r ...
Ramya Rajagopal, Florence Bohnes, Predrag Kukic, Giles Rigarlsford, Evita Vandenbossche-Goddard, Bruno Campos, Claire Davies, Ian Malcomber, Gavin Maxwell, Sarah Sim   +9 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

A new journal for the emerging field of Regulatory Science

, 2013
The growing popularity of the term “Regulatory Science” and accompanying effort to advance this discipline among regulators and academicians necessitates an accompanying scientific journal, accessible to all and free to authors and readers alike.
Editors, IJRS
core   +1 more source

Smart EV Charging: A Global Review of Promising Practices

World Electric Vehicle Journal, 2019
The electrification of transport in Europe is in the early stages of a market transformation that has the potential to significantly cut emissions in both the transportation and energy sectors, while generating wider benefits for society.
Julia Hildermeier, Christos Kolokathis, Jan Rosenow, Michael Hogan, Catharina Wiese, Andreas Jahn   +5 more
doaj   +1 more source